[Prevention of hepatic metastases in rabbits by administration of an oily anticancer agent into the portal vein].

Abstract

We studied one kind of prophylactic chemotherapy against hepatic metastases. The therapy was carried out with a lymphographic oily contrast medium. Lipiodol, and a high-molecular-weight anticancer agent known as SMANCS. SMANCS was dissolved in Lipiodol by sonication (SMANCS/Lipiodol, 1 mg of SMANCS in 1 ml of Lipiodol). SMANCS/Lipiodol, administered into the portal vein, remained for a long time in the portal vein and was eliminated gradually through the bile and urine. SMANCS/Lipiodol (0.4ml/kg) was injected into the mesenteric vein in rabbits, which were then inoculated with the highly malignant carcinoma VX-2. Rabbits injected with SMANCS/Lipiodol before inoculation had significantly fewer hepatic metastases than the control 12 days later (P less than 0.001). Survival was significantly longer (P less than 0.005; 36.0 +/- 7.7 days) with SMANCS/Lipiodol before inoculation than without treatment (23.5 +/- 3.0 days). Hepatic metastases might thus be prevented by portal administration of an appropriate oily anticancer agent.

• Authors: K Yamasaki, T Konno, Y Miyauchi, H Maeda
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 14 Issue 5 Pt 1 Pg. 1224-8 (May 1987) ISSN: 0385-0684 [Print] Japan
• PMID: 3034169 (Publication Type: Journal Article)

Chemical References

• Antibiotics, Antineoplastic
• Furans
• Maleic Anhydrides
• Polystyrenes
• poly(maleic acid-styrene)neocarzinostatin
• Iodized Oil
• Zinostatin

Topics

• Animals
• Antibiotics, Antineoplastic (administration & dosage)
• Furans (administration & dosage)
• Injections, Intravenous
• Iodized Oil (administration & dosage)
• Liver (pathology)
• Liver Neoplasms (pathology, prevention & control, secondary)
• Maleic Anhydrides (administration & dosage)
• Polystyrenes (administration & dosage)
• Portal Vein (diagnostic imaging)
• Rabbits
• Radiography
• Zinostatin (administration & dosage, analogs & derivatives)