Abstract |
In order to meet the unmet medical needs for effective cancer treatment, multifunctional nanocarriers based on iron oxide nanoparticles hold tremendous promise. Here we report a superparamagnetic iron oxide nanoparticles based hexa-functional nanosystem for synergistic cancer theranostic applications by offering active tumour targeting, accumulation and complementary imaging capability by combining magnetic resonance imaging as well as near-infrared fluorescence, magnetophotothermia and chemotherapy. The uniquely designed nanosystem exhibited a paramount increase in the antitumour efficacy through the simultaneous application of multiple thermal effects called magnetophotothermia, which outweighed the therapeutic efficacy of the current thermo-chemo therapies or stand-alone therapies. The active tumour-seeking property with prolonged tumour accumulation and complementary imaging capability with improved sensitivity and resolution also augments the therapeutic efficacy of the proposed nanosystem. Additionally, the work proposes a deep-learning-based tumour cell nuclei detection technique from H&E stained images in anticipation of providing much inspiration for the future of precision histology.
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Authors | Arathyram Ramachandra Kurup Sasikala , Afeesh Rajan Unnithan , Reju George Thomas , Tumurbaatar Batgerel , Yong Yeon Jeong , Chan Hee Park , Cheol Sang Kim |
Journal | Nanoscale
(Nanoscale)
Vol. 10
Issue 41
Pg. 19568-19578
(Nov 07 2018)
ISSN: 2040-3372 [Electronic] England |
PMID | 30324948
(Publication Type: Journal Article)
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Chemical References |
- Biocompatible Materials
- Drug Carriers
- Magnetite Nanoparticles
- Chitosan
- Paclitaxel
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Topics |
- Animals
- Biocompatible Materials
(chemistry, pharmacology)
- Cell Line, Tumor
- Cell Survival
(drug effects)
- Chitosan
(chemistry)
- Drug Carriers
(chemistry, metabolism)
- Humans
- Magnetic Resonance Imaging
- Magnetite Nanoparticles
(chemistry)
- Male
- Mice
- Mice, Inbred BALB C
- Mice, Nude
- NIH 3T3 Cells
- Neoplasms
(diagnostic imaging, drug therapy, pathology)
- Paclitaxel
(administration & dosage, chemistry)
- Theranostic Nanomedicine
- Transplantation, Heterologous
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