Abstract | BACKGROUND: METHODS: We systematically reviewed literature on the association between maternal or neonatal thyroid hormones and ADHD diagnosis or symptoms. We searched Embase, Pubmed, Cinahl, PsycInfo, ERIC, Medline, Scopus, and Web of Science for articles published or available ahead of print as of April 2018. RESULTS: CONCLUSIONS: The reviewed articles suggest an association between maternal thyroid function and ADHD, and possibly between early-treated congenital hypothyroidism and ADHD. Study limitations, however, weaken the conclusions in our systematic review, underlining the need for more research. Importantly, there was much variation in the measurement of thyroid hormone function and of ADHD symptoms. Recommendations for future research include using population-based designs, attending to measurement issues for thyroid hormones and ADHD, considering biologically relevant covariates (e.g., iodine intake), and assessing nonlinear dose-responses.
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Authors | Samantha S M Drover, Gro D Villanger, Heidi Aase, Thea S Skogheim, Matthew P Longnecker, R Thomas Zoeller, Ted Reichborn-Kjennerud, Gun P Knudsen, Pål Zeiner, Stephanie M Engel |
Journal | Epidemiology (Cambridge, Mass.)
(Epidemiology)
Vol. 30
Issue 1
Pg. 130-144
(01 2019)
ISSN: 1531-5487 [Electronic] United States |
PMID | 30299402
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, N.I.H., Intramural, Systematic Review)
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Chemical References |
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Topics |
- Attention Deficit Disorder with Hyperactivity
(epidemiology)
- Child
- Congenital Hypothyroidism
(epidemiology)
- Female
- Humans
- Infant, Newborn
- Maternal-Fetal Exchange
- Pregnancy
- Thyroid Gland
(metabolism)
- Thyroid Hormones
(metabolism)
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