Prophylactic efficacy of immune serum globulin against hepatitis A.

Abstract

A remarkable decline in the morbidity of hepatitis A was observed in the members of the Japan Overseas Cooperation Volunteers (JOCV) following inoculation of these volunteer workers with human immune serum globulin (ISG) once every 4-6 months, a program which was started in 1981 on a voluntary basis. The morbidity rate of hepatitis A declined from 3.5% in 1980 to 0.6% in 1983 and 1984. A significant difference in the morbidity of hepatitis A was observed among those who were not. In addition to precautions about drinking water and fresh or uncooked foods, inoculation with ISG for the prophylaxis against hepatitis A is recommended when non-immune subjects from a developed country travel to or stay in developing countries.

• Authors: H Ohara, I Ebisawa, S Ohtani
• Journal: The Japanese journal of experimental medicine (Jpn J Exp Med) Vol. 56 Issue 5 Pg. 229-33 (Oct 1986) ISSN: 0021-5031 [Print] Japan
• PMID: 3027432 (Publication Type: Journal Article)

Chemical References

• Antibodies, Viral

Topics

• Adult
• Antibodies, Viral (administration & dosage)
• Developing Countries
• Female
• Hepatitis A (prevention & control)
• Hepatovirus (immunology)
• Humans
• Immunization, Passive
• Male
• Travel