Correlation of variable repeat number in the neck regions of DC-SIGN and DC-SIGNR with susceptibility to nasopharyngeal carcinoma in a Chinese population.

Abstract

OBJECTIVE:

To evaluate the potential association of variations in the number of tandem repeats in the dendritic cell-specific intercellular adhesion molecule-3 grabbing nonintegrin (DC-SIGN) and dendritic cell-specific intercellular adhesion molecule-3 grabbing nonintegrin-related (DC-SIGNR) neck region with susceptibility to nasopharyngeal carcinoma (NPC).

METHODS:

Variations in the number of repeats in the genotypes and alleles in the neck region of DC-SIGN/DC-SIGNR were analyzed in 477 unrelated NPC patients and 561 cancer-free controls.

RESULTS:

Genotypes and alleles in the DC-SIGN neck region did not differ significantly between NPC patients and controls, but the 9-repeat genotype in the DC-SIGNR neck region was significantly more frequent among patients (OR 1.339, 95% CI 1.018-1.760, P=0.037). The association between this genotype and NPC remained significant after adjusting for sex, age, smoking history, and presence of immunoglobulin against Epstein-Barr virus viral capsid antigen (OR 1.625, 95% CI 1.134-2.329, P=0.0082).

CONCLUSION:

These results suggest that genotypes/alleles in the DC-SIGN neck region are not associated with NPC susceptibility, whereas the 9-repeat variant in the neck region of DC-SIGNR may increase the risk of NPC.

• Authors: Sisi Ning, Mengwei Yao, Yuan Wu, Xunzhao Zhou, Changtao Zhong, Kui Yan, Zhengbo Wei, Ying Xie
• Journal: Cancer management and research (Cancer Manag Res) Vol. 10 Pg. 3193-3198 ( 2018) ISSN: 1179-1322 [Print] New Zealand
• PMID: 30233235 (Publication Type: Journal Article)