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Effect of pore geometry on the fatigue properties and cell affinity of porous titanium scaffolds fabricated by selective laser melting.

Abstract
Porous titanium scaffolds with different unit cell type (tetrahedron and octahedron) and pore size (500 µm and 1000 µm) were fabricated by selective laser melting (SLM), and the effects of unit cell type and pore size on their fatigue properties and cell affinity were studied. The fatigue properties were performed by static and dynamic mechanical testing, while the cell affinity was evaluated in vitro with mouse osteoblast cells. It was found that octahedron scaffolds exhibited superior static mechanical properties, longer fatigue lives and higher fatigue strength in comparison to those of tetrahedron ones. As expected, scaffolds with 1000 µm pore resulted in lower compressive properties and shorter fatigue lives compared to those with 500 µm pore. The differences were analyzed based on the unit cell structure, porosity, and manufacturing imperfections. Scanning electron microscopy (SEM) and immunofluorescence showed that cells spread better on octahedron scaffolds than those on tetrahedron ones. Meanwhile, the scaffolds with 1000 µm pore were more suitable for cell attachment and growth within the same unit cell owing to higher porosity. The comparison of different pore geometry on the mechanical and biological property provided further insight into designing an optimal porous scaffold.
AuthorsDanlei Zhao, Yutian Huang, Yong Ao, Changjun Han, Qian Wang, Yan Li, Jie Liu, Qingsong Wei, Zhen Zhang
JournalJournal of the mechanical behavior of biomedical materials (J Mech Behav Biomed Mater) Vol. 88 Pg. 478-487 (12 2018) ISSN: 1878-0180 [Electronic] Netherlands
PMID30223211 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2018 Elsevier Ltd. All rights reserved.
Chemical References
  • Biocompatible Materials
  • Titanium
Topics
  • 3T3 Cells
  • Animals
  • Biocompatible Materials (chemistry, pharmacology)
  • Compressive Strength
  • Lasers
  • Mice
  • Models, Molecular
  • Molecular Conformation
  • Osteoblasts (cytology, drug effects)
  • Porosity
  • Stress, Mechanical
  • Titanium (chemistry, pharmacology)

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