Impact of Valve Culture in the Prognosis of Active Left-sided Infective Endocarditis.

Abstract

BACKGROUND:

The culture of removed cardiac tissues during cardiac surgery of left-sided infective endocarditis (LSIE) helps to guide antibiotic treatment. Nevertheless, the prognostic information of a positive valve culture has never been explored.

METHODS:

Among 1078 cases of LSIE consecutively diagnosed in 3 tertiary centers, we selected patients with positive blood cultures who underwent surgery during the active period of infection and in whom surgical biological tissues were cultured (n = 429). According to microbiological results, we constructed 2 groups: negative valve culture (n=218) and concordant positive valve culture (CPVC) (n=118). We compared their main features and performed a multivariable analysis of in-hospital mortality.

RESULTS:

Patients with CPVC presented more nosocomial origin (32% vs 20%, P = .014), more septic shock (21% vs 11%, P = .007), and higher Risk-E score (29% vs 21%, P = .023). Their in-hospital mortality was higher (35% vs 19%, P = .001), despite an earlier surgery (3 vs 11 days from antibiotic initiation, P < .001). Staphylococcus species (61% vs 42%, P = .001) and Enterococcus species (20% vs 9%, P = .002) were more frequent in the CPVC group, whereas Streptococcus species were less frequent (14% vs 42%, P < .001). Independent predictors for in-hospital mortality were renal failure (odds ratio [OR], 2.6 [95% confidence interval {CI}, 1.5-4.4]), prosthesis (OR, 1.9 [95% CI, 1.1-3.5]), Staphylococcus aureus (OR, 1.8 [95% CI, 1.02-3.3]), and CPVC (OR, 2.3 [95% CI, 1.4-3.9]).

CONCLUSIONS:

Valve culture in patients with active LSIE is an independent predictor of in-hospital mortality.

• Authors: Pablo Elpidio García-Granja, Javier López, Isidre Vilacosta, Cristina Sarriá, Raquel Ladrón, Carmen Olmos, Carmen Sáez, Luis Maroto, Salvatore Di Stefano, Itziar Gómez, J Alberto San Román, Endocarditis and Valvulopathies (ENDOVAL) Group
• Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (Clin Infect Dis) Vol. 68 Issue 6 Pg. 1017-1023 (03 05 2019) ISSN: 1537-6591 [Electronic] United States
• PMID: 30107544 (Publication Type: Journal Article, Multicenter Study)
• Copyright: © The Author(s) 2018. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: [email protected].

Topics

• Adult
• Aged
• Cardiac Surgical Procedures (adverse effects)
• Comorbidity
• Disease Susceptibility
• Endocarditis (diagnosis, etiology, mortality, surgery)
• Female
• Heart Diseases (complications, surgery)
• Heart Valves (microbiology, surgery)
• Hospital Mortality
• Humans
• Male
• Middle Aged
• Prognosis
• Prosthesis-Related Infections