Epilepsy treatment patterns among patients with tuberous sclerosis complex.

Abstract

INTRODUCTION:

Tuberous sclerosis complex (TSC) is a rare congenital disorder often associated with epilepsy. However, real-world treatment patterns for epilepsy in patients with TSC are not yet well categorized.

METHODS:

This study included patients with TSC and epilepsy from fifteen clinics in the United States and one in Belgium who were enrolled in the TSC Natural History Database (2006-2014). Patient demographics and epilepsy treatment patterns, including the use of anti-epileptic drugs (AEDs), epilepsy surgeries, and dietary therapies were assessed.

RESULTS:

Of the 1328 patients with TSC in the database, 1110 (83.6%) were diagnosed with epilepsy. The median age of epilepsy diagnosis was 0.7 years. Of those who received treatment for epilepsy (92.3%), 99.5% were prescribed AEDs, 25.3% underwent surgery, 7.9% were prescribed special diets, and 1% were prescribed mammalian target of rapamycin (mTOR) inhibitors. Of the patients receiving AEDs, over half (64.5%) used ≥3 different AEDs, and 22.5% underwent surgical treatment following AED initiation. Of the patients who underwent surgery, 35.1% had subsequent surgery.

CONCLUSION:

The use of multiple AEDs and surgical interventions may indicate a need for new therapies to reduce the treatment burden among patients with TSC and epilepsy.

• Authors: Jinlin Song, Elyse Swallow, Qayyim Said, Miranda Peeples, Mark Meiselbach, James Signorovitch, Michael Kohrman, Bruce Korf, Darcy Krueger, Michael Wong, Steven Sparagana
• Journal: Journal of the neurological sciences (J Neurol Sci) Vol. 391 Pg. 104-108 (08 15 2018) ISSN: 1878-5883 [Electronic] Netherlands
• PMID: 30103955 (Publication Type: Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2018. Published by Elsevier B.V.

Chemical References

• Anticonvulsants

Topics

• Adolescent
• Anticonvulsants (therapeutic use)
• Child
• Child, Preschool
• Diet Therapy (trends)
• Epilepsy (complications, epidemiology, genetics, therapy)
• Female
• Follow-Up Studies
• Humans
• Male
• Neurosurgical Procedures (trends)
• Retrospective Studies
• Treatment Outcome
• Tuberous Sclerosis (complications, epidemiology, genetics, therapy)
• Young Adult