Serum cyclophilin A concentrations and prognosis of acute intracerebral hemorrhage.

Abstract

BACKGROUND:

Cyclophilin A is involved in brain injury. We investigated the relationship between serum cyclophilin A concentrations, hemorrhagic severity and clinical outcome in intracerebral hemorrhage (ICH).

METHODS:

We enrolled 105 ICH patients and 105 healthy individuals. Admission serum cyclophilin A concentrations were detected in ICH patients. Hemorrhagic severity was assessed using the National Institutes of Health Stroke Scale (NIHSS) and hematoma volume. Modified Rankin Scale score > 2 was defined as a poor outcome.

RESULTS:

Serum cyclophilin A concentrations were significantly higher in patients than in controls. There was a close correlation of serum cyclophilin A concentrations with NIHSS scores and hematoma volume. Serum cyclophilin A emerged as an independent predictor for 6-month mortality, overall survival and poor outcome. Moreover, it had a strong discriminatory ability for 6-month mortality and poor outcome. Furthermore, it could significantly improve the prognostic predictive ability of NIHSS scores or hematoma volume alone.

CONCLUSIONS:

Increasted serum cyclophilin A concentrations are highly associated with stroke severity and prognosis after hemorrhagic stroke.

• Authors: Bin Chen, Jia Shen, Guan-Rong Zheng, Shen-Zhong Qiu, Huai-Ming Yin, Wei Mao, Hong-Xiang Wang, Jian-Bo Gao
• Journal: Clinica chimica acta; international journal of clinical chemistry (Clin Chim Acta) Vol. 486 Pg. 162-167 (Nov 2018) ISSN: 1873-3492 [Electronic] Netherlands
• PMID: 30077639 (Publication Type: Journal Article, Observational Study)
• Copyright: Copyright © 2018 Elsevier B.V. All rights reserved.

Chemical References

• Cyclophilin A

Topics

• Acute Disease
• Aged
• Cerebral Hemorrhage (blood, diagnosis)
• Cyclophilin A (blood)
• Female
• Humans
• Male
• Middle Aged
• Prospective Studies
• Survival Rate