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Case of cryptococcal choroiditis in adult with T-cell leukemia/lymphoma.

Abstract
A rare case of 70-year-old woman with adult T-cell leukemia/lymphoma who developed multifocal choroiditis from a dissemination of Cryptococcus neoformans is reported. Ophthalmologic examination revealed multiple yellowish choroidal lesions in the posterior pole of both eyes. Sequential optical coherence tomographic images disclosed the involvement of the choroid and the consecutive changes in its architecture during the course of treatment. The recognition of these ocular manifestations may be important for the rapid diagnosis of C. nerformans-disseminated diseases. Rapid diagnosis and prompt therapy with intravitreal injection as well as systemic fosfluconazole and liposomal amphotericin B led to clinical improvement of intraocular cryptococcosis.
AuthorsWataru Yamada, Hiroki Yamada, Kazuhiro Murata, Hiroshi Kosugi, Yuko Asano, Kiyofumi Mochizuki, Kyoko Ishida
JournalJournal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy (J Infect Chemother) Vol. 25 Issue 1 Pg. 59-64 (Jan 2019) ISSN: 1437-7780 [Electronic] Netherlands
PMID30057340 (Publication Type: Case Reports, Journal Article)
CopyrightCopyright © 2018 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.
Chemical References
  • Antifungal Agents
  • Organophosphates
  • liposomal amphotericin B
  • fosfluconazole
  • Amphotericin B
  • Fluconazole
Topics
  • Aged
  • Amphotericin B (administration & dosage, therapeutic use)
  • Antifungal Agents (administration & dosage, therapeutic use)
  • Choroiditis (blood, diagnosis, drug therapy, microbiology)
  • Cryptococcosis (complications, diagnosis)
  • Cryptococcus neoformans (drug effects, genetics, isolation & purification)
  • Eye (pathology)
  • Eye Infections, Fungal (blood, complications, diagnosis, drug therapy)
  • Fatal Outcome
  • Female
  • Fluconazole (administration & dosage, analogs & derivatives, therapeutic use)
  • Humans
  • Intravitreal Injections
  • Leukemia-Lymphoma, Adult T-Cell (blood, complications, drug therapy)
  • Multifocal Choroiditis
  • Organophosphates (administration & dosage, therapeutic use)
  • Tomography, Optical Coherence

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