Abstract | OBJECTIVES: METHODS: This cross-sectional study was conducted during a 2-year period in a gynecologic oncology referral center in Southern Iran. We included a total number of 94 patients with endometrial cancer. Preoperative assessment included tumor volume, myometrium invasion, histology, and CA125. The KCC was calculated for all the patients. All the patients underwent total abdominal hysterectomy and bilateral salpingo-oophorectomy along with dissection of pelvic and para-aortic lymph nodes. The histopathology of the dissected lymph nodes was considered as criterion standard, and the predictive value of KCC was evaluated accordingly. RESULTS: The mean ± SD age of the patients was 56.8 ± 10.2 years. Overall, 26 patients (27.7%) tested positive for lymph node involvement. The sensitivity, specificity, positive predictive value, and negative predictive value of KCC for lymph node involvement was found to be 35.3%, 100%, 100%, and 64.7%, respectively. Overall, the predictive value according to the area under the curve measured by receiver operating characteristic curve was found to be 0.890 (0.823-0.956) indicative of moderate accuracy. Lymph node involvement was associated with higher Federation of Gynecology and Obstetrics stage (P < 0.001), higher tumor volume (P = 0.003), higher histological subtype (P < 0.001), positive CA125 (P < 0.001), and higher KCC score (P < 0.001). CONCLUSIONS: The KCC scoring system has a moderate accuracy for predicting the lymph node involvement in patients with endometrial cancer.
|
Authors | Mozhdeh Momtahan, Marjan Hosseini, Minoo Robati, Fatemesadat Najib |
Journal | International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
(Int J Gynecol Cancer)
Vol. 28
Issue 7
Pg. 1290-1296
(09 2018)
ISSN: 1525-1438 [Electronic] England |
PMID | 29994911
(Publication Type: Journal Article, Validation Study)
|
Topics |
- Cross-Sectional Studies
- Endometrial Neoplasms
(diagnosis, pathology, surgery)
- Female
- Humans
- Logistic Models
- Lymph Node Excision
- Lymph Nodes
(pathology, surgery)
- Lymphatic Metastasis
- Middle Aged
- Predictive Value of Tests
- Severity of Illness Index
|