Diffusion-weighted magnetic resonance imaging-directed biopsy of a metastatic bone tumor: Lung adenocarcinoma with ALK rearrangement.

Abstract

A previously healthy 44-year-old Japanese man with a 5-month history of lumbago presented to the emergency department with acute respiratory failure caused by pneumonia, and was immediately intubated. Computed tomography revealed a lung mass, pleural effusion, and multiple osteolytic lesions; however, the results of thoracentesis and bronchial brushing were not definitive. We performed a bone tumor biopsy guided by diffusion-weighted magnetic resonance imaging (DW-MRI) with mechanical ventilation, which enabled the diagnosis of ALK rearrangement-positive lung adenocarcinoma. In the era of precision medicine requiring proper biological tissue collection, DW-MRI was critical for identifying the biopsy site safely and with high precision.

• Authors: Makoto Hibino, Yuka Otsuka, Kazunari Maeda, Shigeto Horiuchi, Minoru Fukuda, Tetsuri Kondo
• Journal: Respiratory medicine case reports (Respir Med Case Rep) Vol. 24 Pg. 170-172 ( 2018) ISSN: 2213-0071 [Print] England
• PMID: 29977788 (Publication Type: Case Reports)