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A Glycolysis Outsider Steps into the Cancer Spotlight.

Abstract
Glycolysis is prudently regulated and coupled to cell growth. Phosphofructokinase 2 controls glycolytic flux by generating fructose 2,6-bisphosphate, an allosteric activator of phosphofructokinase 1. In a recent paper in Nature, Dasgupta et al. address the novel role of PFKFB4, an isoform of phosphofructokinase 2, in regulating gene expression to promote tumor growth.
AuthorsMarcus D Goncalves, Lewis C Cantley
JournalCell metabolism (Cell Metab) Vol. 28 Issue 1 Pg. 3-4 (07 03 2018) ISSN: 1932-7420 [Electronic] United States
PMID29972796 (Publication Type: Journal Article, Comment)
CopyrightCopyright © 2018 Elsevier Inc. All rights reserved.
Chemical References
  • PFKFB4 protein, human
  • Phosphofructokinase-2
  • Phosphofructokinase-1
Topics
  • Breast Neoplasms
  • Cell Proliferation
  • Glycolysis
  • Humans
  • Phosphofructokinase-1
  • Phosphofructokinase-2

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