Clinical efficiency of repeated pulmonary metastasectomy in sarcoma patients with recurrent pulmonary metastasis: A meta-analysis.

Abstract

INTRODUCTION:

Recurrent pulmonary metastasis is common in sarcoma patients following the first pulmonary metastasectomy. Repeated pulmonary metastasectomy (RPM) may be a possible treatment method, but it has several unfavorable aspects. The clinical efficiency of RPM has not been established, as previous studies have reached inconsistent results.

MATERIALS AND METHODS:

Comprehensively literature searches were conducted in PubMed, Web of Science, Embase, and Cochrane Library. All eligible articles were included according to inclusion criteria. Then, a meta-analysis was conducted to clarify the clinical efficiency of RPM.

RESULTS:

A total of 9 articles with 464 patients were included. We found that sarcoma patients with recurrent pulmonary metastasis that underwent RPM had significantly better overall survival (hazard ratio = 0.59; 95% confidence interval, 0.44-0.81; P = 0.001). No significant publication bias was found. Sensitivity analysis showed the results were stable.

CONCLUSION:

Selected sarcoma patients with recurrent pulmonary metastasis following the first pulmonary metastasectomy could still benefit from RPM, despite its unfavorable aspects.

• Authors: Yongjiang Li, Wenbiao Zhang, Shuangjiang Li, Chongqi Tu
• Journal: Journal of cancer research and therapeutics (J Cancer Res Ther) Vol. 14 Issue Supplement Pg. S457-S462 (Jun 2018) ISSN: 1998-4138 [Electronic] India
• PMID: 29970706 (Publication Type: Journal Article, Meta-Analysis)

Topics

• Humans
• Lung Neoplasms (secondary, surgery)
• Metastasectomy (methods)
• Odds Ratio
• Pneumonectomy (methods)
• Proportional Hazards Models
• Publication Bias
• Recurrence
• Sarcoma (pathology)
• Treatment Outcome