Efficacy of afoxolaner in the treatment of otodectic mange in naturally infested cats.

Abstract

Afoxolaner is a drug belonging to the isoxazolines' family, and it is recommended for ectoparasite control in dogs. The objective of this study was to evaluate the efficacy of afoxolaner in the treatment of otodectic mange in naturally infested cats. Sixteen cats were divided into two groups (treated and control). The treated group (n = 8) underwent a single oral presentation of afoxolaner at a dose of 2.5 mg/kg. The control group (n = 8) received no antiparasitic treatment. The detection of mite infestations were performed by video otoscopy before the medication, 48 h after the medication and at weekly intervals up to 35 days after treatment (+7, +14, +21, +28, +35). In the treated group, the animals were negative for the presence of the mite 48 h after the medication and throughout the evaluation period. The control group remained positive throughout the experiment, demonstrating 100% efficacy (p < 0.05) for the treated cats naturally infested with Otodectes cynotis in a single dose over a period of 35 days. The animals were reintroduced into their natural habitat, allowed to regain contact with other cats and then reassessed for possible reinfestation. It was found that afoxolaner was effective in the treatment of otodectic mange the animals presented no adverse reaction to the use of afoxolaner.

• Authors: Marília Alves Machado, Diefrey Ribeiro Campos, Natália Lôres Lopes, Isabela Pessôa Barbieri Bastos, Cristiane Bazaga Botelho, Thais Ribeiro Correia, Fábio Barbour Scott, Julio Israel Fernandes
• Journal: Veterinary parasitology (Vet Parasitol) Vol. 256 Pg. 29-31 (May 30 2018) ISSN: 1873-2550 [Electronic] Netherlands
• PMID: 29887026 (Publication Type: Journal Article)
• Copyright: Copyright © 2018 Elsevier B.V. All rights reserved.

Chemical References

• Acaricides
• Isoxazoles
• Naphthalenes
• afoxolaner

Topics

• Acaricides (therapeutic use)
• Animals
• Cat Diseases (drug therapy)
• Cats
• Isoxazoles (therapeutic use)
• Mite Infestations (drug therapy, veterinary)
• Naphthalenes (therapeutic use)
• Treatment Outcome