Abstract |
We performed a meta-analysis to determine whether combination therapy with serotonin reuptake inhibitors (SRIs) and memantine (MEM) was beneficial for the treatment of obsessive- compulsive disorder. This study included three double-blind, randomized, placebo-controlled trials. MEM+SRI was superior to placebo+SRI with regard to response rate [primary outcome, n = 97; risk ratio = 0.22; 95% confidence intervals (CI) = 0.12-0.42; p < 0.00001; I2 = 0%; number needed to treat = 2], the Yale- Brown Obsessive- Compulsive Scale total [standardized mean difference (SMD) = - 4.56; 95% CI = - 8.50, - 0.62; p = 0.02], obsession subscale (SMD = - 4.39; 95% CI = - 5.94, - 2.85; p < 0.00001), and compulsion subscale score (SMD = - 4.60; 95% CI = - 7.64, - 1.55; p = 0.003). No significant differences in any safety outcome were found between the groups.
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Authors | Taro Kishi, Yuki Matsuda, Nakao Iwata |
Journal | Journal of Alzheimer's disease : JAD
(J Alzheimers Dis)
Vol. 64
Issue 1
Pg. 43-48
( 2018)
ISSN: 1875-8908 [Electronic] Netherlands |
PMID | 29865079
(Publication Type: Journal Article)
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Chemical References |
- Excitatory Amino Acid Antagonists
- Serotonin Uptake Inhibitors
- Memantine
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Topics |
- Adult
- Double-Blind Method
- Excitatory Amino Acid Antagonists
(therapeutic use)
- Female
- Humans
- Male
- Memantine
(therapeutic use)
- Meta-Analysis as Topic
- Obsessive-Compulsive Disorder
(drug therapy)
- Randomized Controlled Trials as Topic
- Selective Serotonin Reuptake Inhibitors
(therapeutic use)
- Young Adult
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