PD-L1 Expression Predicts a Distinct Prognosis in Krukenberg Tumor with Corresponding Origins.

Abstract

Krukenberg tumor (KT) is an uncommon ovarian metastatic signet-ring cell adenocarcinoma that mostly metastasizes from gastrointestinal carcinoma. Optimal treatment options for KTs are limited. Programmed death-1 (PD-1)/programmed death-ligand 1 (PD-L1) inhibitors have shown remarkable activity in clinical trials for metastatic tumors. Here, we evaluated PD-L1 expression and T cell infiltration in KTs and their corresponding primary tumors. Positive tumor PD-L1 expression was detected in 9 (25.7%) KTs from gastric carcinomas (GCs) and in 20 (66.7%) KTs from colorectal carcinomas (CRCs). Patient survival was assessed according to the PD-L1 status and CD8+ T cell density. Positive tumor PD-L1 expression in KTs from GCs was associated with poor prognosis. In contrast, positive tumor PD-L1 expression in KTs from CRCs was associated with an improved prognosis. We analyzed copy number variations of the PD-L1 gene in KTs. PD-L1 expression was higher in cases with copy number gains. The T cell densities within KTs and their corresponding primary tumors were compared. The densities of CD8+ T cells correlated significantly between the primary tumors and KTs from the same case. Taken together, the research further highlighted targets for immune-based therapy in KTs from GCs and CRCs.

• Authors: Haiyan Tai, Qin Yang, Zhiyong Wu, Su'an Sun, Rui Cao, Yanfeng Xi, Ran Zhao, Mengyu Zhang, Zhigang Zhang, Congjian Xu
• Journal: Journal of immunology research (J Immunol Res) Vol. 2018 Pg. 9485285 ( 2018) ISSN: 2314-7156 [Electronic] Egypt
• PMID: 29854854 (Publication Type: Journal Article)

Chemical References

• Antibodies, Monoclonal
• B7-H1 Antigen
• Pdcd1 protein, mouse
• Programmed Cell Death 1 Receptor

Topics

• Adenocarcinoma (diagnosis, mortality, secondary)
• Adult
• Antibodies, Monoclonal (therapeutic use)
• B7-H1 Antigen (genetics, immunology, metabolism)
• CD8-Positive T-Lymphocytes (immunology)
• Cohort Studies
• Colonic Neoplasms (diagnosis, mortality, pathology)
• Female
• Gene Dosage
• Humans
• Immunohistochemistry
• Immunotherapy (methods)
• Krukenberg Tumor (diagnosis, mortality, secondary)
• Middle Aged
• Ovarian Neoplasms (diagnosis, mortality, secondary)
• Polymorphism, Genetic
• Predictive Value of Tests
• Prognosis
• Programmed Cell Death 1 Receptor (metabolism)
• Retrospective Studies
• Stomach Neoplasms (diagnosis, mortality, pathology)
• Survival Analysis
• Young Adult