Medical Therapy for Cushing's Syndrome in the Twenty-first Century.

Abstract

Medical therapy has a useful adjunctive role in many patients with Cushing's syndrome. Patients with pituitary corticotroph adenomas who have received radiation therapy to the sella require medical therapy until the effects of radiation therapy occur. In addition, patients with Cushing's syndrome who cannot undergo surgery promptly, including those who are acutely ill and cannot safely undergo tumor resection, may benefit from medical therapy as a bridge to surgery. Other possible candidates for medical therapy are those with unresectable tumors or those whose tumor location remains unknown despite adequate diagnostic evaluation.

• Authors: Nicholas A Tritos, Beverly M K Biller
• Journal: Endocrinology and metabolism clinics of North America (Endocrinol Metab Clin North Am) Vol. 47 Issue 2 Pg. 427-440 (06 2018) ISSN: 1558-4410 [Electronic] United States
• PMID: 29754642 (Publication Type: Journal Article, Review)
• Copyright: Copyright © 2018 Elsevier Inc. All rights reserved.

Chemical References

• Antimetabolites
• Antineoplastic Agents, Hormonal
• Enzyme Inhibitors
• Hormones
• Neurotransmitter Agents
• Receptors, Glucocorticoid

Topics

• Antimetabolites (adverse effects, pharmacology)
• Antineoplastic Agents, Hormonal (adverse effects, pharmacology)
• Cushing Syndrome (drug therapy)
• Enzyme Inhibitors (adverse effects, pharmacology)
• Hormones (adverse effects, pharmacology)
• Humans
• Neurotransmitter Agents (adverse effects, pharmacology)
• Receptors, Glucocorticoid (antagonists & inhibitors)