[Correlation analysis of "compound-target-pathway" of Yinchenhao decoction for cirrhosis based on computed prediction].

Abstract

Chinese medicine prescription is the main form and means to treat diseases in traditional Chinese medicine (TCM). However, the disjointing situation is generally present between "systemic" and "local", "macro" and "micro", "in vivo process" and "activity evaluation" in the study of TCM at present. An urgent task for the modernization of TCM is to establish new strategies and methods which can reflect the overall characteristics of TCM. The introduction of integrative pharmacology provided a feasible approach to solve the problem of the fragmentation of TCM. Internet-based computation platform method was adopted in this study to explore the active molecular mechanism of Yinchenhao decoction in the treatment of cirrhosis. Based on the analysis of the functional integration of Internet-based Computation Platform V1.0 version software, the "core components-key target- main pathway" multidimensional network of Yinchenhao decoction in treatment of cirrhosis disease was constructed to explore the potential molecular mechanism of Yinchenhao decoction in treatment of cirrhosis from multiple perspectives. The molecular mechanism analysis of Yinchenhao decoction showed that Yinchenhao decoction can achieve the therapeutic effect on cirrhosis and the mechanism might be associated with oxidative phosphorylation, energy metabolism, circulatory system, glycerophospholipid metabolis, lipid metabolism and other pathways. Yinchenhao decoction in treatment of cirrhosis may be associated with energy metabolism and lipid metabolism.

• Authors: Lei Yang, Meng-Jiao Liu, Zhi-Guo Zhang, Qin Zhang, Wen-Ming Chen, Yong Huang, Ping Wu
• Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica (Zhongguo Zhong Yao Za Zhi) Vol. 43 Issue 7 Pg. 1345-1351 (Apr 2018) ISSN: 1001-5302 [Print] China
• PMID: 29728022 (Publication Type: Journal Article)
• Copyright: Copyright© by the Chinese Pharmaceutical Association.

Chemical References

• Drugs, Chinese Herbal
• yinchenhao

Topics

• Drugs, Chinese Herbal (therapeutic use)
• Energy Metabolism
• Humans
• Lipid Metabolism
• Liver Cirrhosis (drug therapy)
• Medicine, Chinese Traditional