Abstract |
Peripheral monocytes have recently been evaluated as a prognostic factor in different types of hematological malignancies. This study assessed the prognostic value of absolute monocyte count (AMC) post-transplant on the clinical outcomes of 59 patients with acute myeloid leukemia (AML) who had undergone myeloablative conditioning (MAC) allogeneic hematopoietic stem cell transplant (allo-HSCT) with busulfan and cyclophosphamide (Bu/Cy). Kaplan-Meier analysis showed that patients with a high AMC (≥ 0.57 × 109/L) on post-transplant day (PTD) 15 had a significantly worse overall survival (OS) compared to patients with a low AMC (< 0.57 × 109/L) on PTD 15 (P = .0049). Univariate Cox proportional hazard analyses revealed that only high AMC on PTD 15 was a poor prognostic factor for OS (P = .008) and post-relapse survival (P = .030). We conclude that AMC ≥ 0.57 × 109/L on PTD 15 is associated with more deaths in patients with AML who have undergone MAC allo-HSCT with Bu/Cy.
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Authors | Liyuan Tang, Na Wang, Chongyun Xing, Qiang Zhuang, Bin Liang, Lan Sun, Yi Chen, Yan Qian, Zhijian Shen, Songfu Jiang, Kang Yu, Jianhua Feng |
Journal | Leukemia research
(Leuk Res)
Vol. 69
Pg. 60-65
(06 2018)
ISSN: 1873-5835 [Electronic] England |
PMID | 29660493
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2018 Elsevier Ltd. All rights reserved. |
Chemical References |
- Myeloablative Agonists
- Cyclophosphamide
- Busulfan
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Topics |
- Adolescent
- Adult
- Antineoplastic Combined Chemotherapy Protocols
(administration & dosage)
- Busulfan
(administration & dosage)
- Child
- Child, Preschool
- Cyclophosphamide
(administration & dosage)
- Female
- Hematopoietic Stem Cell Transplantation
- Humans
- Kaplan-Meier Estimate
- Leukemia, Myeloid, Acute
(blood, drug therapy, therapy)
- Leukocyte Count
- Male
- Middle Aged
- Monocytes
(cytology)
- Myeloablative Agonists
(administration & dosage)
- Prognosis
- Proportional Hazards Models
- Retrospective Studies
- Transplantation Conditioning
- Treatment Outcome
- Young Adult
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