Predictive factors for treatment response using dual-energy computed tomography in patients with advanced lung adenocarcinoma.

Abstract

PURPOSE:

This study aimed to investigate whether the quantitative parameters of dual-energy computed tomography (DECT) can predict the effects of chemotherapy in advanced adenocarcinoma based on the Response Evaluation Criteria in Solid Tumors (RECIST) guidelines.

MATERIALS AND METHODS:

A total of 90 patients (59 males, 31 females, age 61.4 ± 12.3 (23-85)) with unresectable lung adenocarcinoma (TNM stage IIIB or IV) who underwent DECT before chemotherapy were prospectively included in this study. By comparing baseline studies with the best response achieved during 1 st line chemotherapy, patients were divided into two groups according to RECIST (version 1.1) guidelines as follows; responders (CR or PR) and non-responders (SD or PD). Quantitative measurements were performed on baseline DECT, and a logistic regression model was used to evaluate predictive factors for a response to chemotherapy.

RESULTS:

Among 90 patients, 38 were categorized as responders, while 52 patients were non-responders. The mean iodine concentration measurements were significantly higher in responders compared with non-responders (1.81 ± 0.51 vs 1.33 ± 0.76 mg/ml, p < 0.001). On multivariate analysis, EGFR mutation (odds ratio (OR): 3.116, 95% confidential interval (CI):1.182-8.213, p = .019) and iodine concentration (OR: 1.112, 95% CI:1.034-1.196, p = .006) were found to be significant for predicting a treatment response.

CONCLUSIONS:

Dual-energy CT using a quantitative analytic method based on iodine concentration measurements can be used to predict the effects of chemotherapy in patients with advanced adenocarcinoma.

• Authors: Sae Rom Hong, Jin Hur, Yong Wha Moon, Kyunghwa Han, Suyon Chang, Jin Young Kim, Dong Jin Im, Young Joo Suh, Yoo Jin Hong, Hye-Jeong Lee, Young Jin Kim, Byoung Wook Choi
• Journal: European journal of radiology (Eur J Radiol) Vol. 101 Pg. 118-123 (Apr 2018) ISSN: 1872-7727 [Electronic] Ireland
• PMID: 29571784 (Publication Type: Journal Article)
• Copyright: Copyright © 2018 Elsevier B.V. All rights reserved.

Chemical References

• Iodine

Topics

• Adenocarcinoma (diagnostic imaging, drug therapy, pathology)
• Adenocarcinoma of Lung
• Adult
• Aged
• Aged, 80 and over
• Female
• Humans
• Iodine
• Lung (diagnostic imaging, pathology)
• Lung Neoplasms (diagnostic imaging, drug therapy, pathology)
• Male
• Middle Aged
• Predictive Value of Tests
• Prospective Studies
• Radiography, Dual-Energy Scanned Projection (methods)
• Response Evaluation Criteria in Solid Tumors
• Tomography, X-Ray Computed (methods)
• Treatment Outcome
• Young Adult