Abstract | PURPOSE: METHODS: 24 patients with acute NAION were included. Retrobulbar hemodynamics were measured using color Doppler imaging before and 15 min after intravenous infusion of 250 cc 10% hydroxyethyl starch (HES). Peak systolic velocity (PSV), end diastolic velocity (EDV), and Pourcelot's resistive index (RI) were measured in the ophthalmic artery (OA), central retinal artery (CRA), and short posterior ciliary arteries (PCAs). RESULTS: After infusion of HES blood flow velocities significantly increased in the CRA (PSV from 7.53 ± 2.33 to 8.32 ± 2.51 (p < 0.001); EDV from 2.16 ± 0.56 to 2.34 ± 0.55 (p < 0.05)) and in the PCAs (PSV from 7.18 ± 1.62 to 7.56 ± 1.55 (p < 0.01); EDV from 2.48 ± 0.55 to 2.66 ± 0.6 cm/sec (p < 0.01)). The RI of all retrobulbar vessels remained unaffected. Blood pressure and heart rate remained unchanged. CONCLUSIONS: Hypervolemic hemodilution has an acute effect on blood flow velocities in the CRA and PCAs in NAION patients. Increased blood flow in the arteries supplying the optic nerve head may lead to a better perfusion in NAION patients. This trial is registered with DRKS00012603.
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Authors | Marion Bienert, Niklas Plange, Andreas Remky, Kay Oliver Arend, David Kuerten |
Journal | BioMed research international
(Biomed Res Int)
Vol. 2018
Pg. 4756313
( 2018)
ISSN: 2314-6141 [Electronic] United States |
PMID | 29546060
(Publication Type: Clinical Trial, Journal Article)
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Chemical References |
- Hydroxyethyl Starch Derivatives
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Topics |
- Aged
- Ciliary Arteries
(diagnostic imaging, drug effects, physiopathology)
- Female
- Hemodilution
(methods)
- Hemodynamics
(drug effects)
- Humans
- Hydroxyethyl Starch Derivatives
(therapeutic use)
- Infusions, Intravenous
- Male
- Ophthalmic Artery
(diagnostic imaging, drug effects)
- Optic Neuropathy, Ischemic
(diagnostic imaging, drug therapy, physiopathology)
- Retinal Artery
(diagnostic imaging, drug effects, physiopathology)
- Rheology
- Ultrasonography, Doppler, Color
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