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Ultrasonographic investigation of cholangiocarcinoma in Lao PDR.

Abstract
Opisthorchis viverrini is a group 1 carcinogen that causes cholangiocarcinoma (CCA). Although opisthorchiasis is known to be severely endemic to several areas along the Mekong River in Lao PDR, the CCA status of residents of this region is still under investigation. In this study, we analyzed the results of abdominal ultrasonography (US) performed on 6113 residents in 9 provinces (Vientiane Municipality, Savannakhet, Phongsaly, Khammouane, Saravane, Champasak, Vientiane, Xieng Khuouang, and Luang Prabang provinces) of Lao PDR from 2007 to 2011. Overall, 51 cases (0.83%) were detected with suspected CCA. The CCA rates in Vientiane Municipality and in Savannakhet and Khammouane provinces were 1.45%, 1.58%, and 1.09%, respectively. However, in the other 6 provinces, the rate of CCA averaged only 0.26%. In the 3 provinces with higher rates of CCA, bile duct dilatation (grade ≥ 2) was also significantly more prevalent (P < 0.0001). These results are concordant with previous reports showing a higher endemicity of opisthorchiasis in Vientiane Municipality and in Savannakhet and Khammouane provinces.
AuthorsJu Yeong Kim, Tai-Soon Yong, Han-Jong Rim, Jong-Yil Chai, Duk-Young Min, Keeseon S Eom, Woon-Mok Sohn, Jae Hoon Lim, Dongil Choi, Sithat Insisiengmay, Bounlay Phommasack, Bounnaloth Insisiengmay
JournalActa tropica (Acta Trop) Vol. 182 Pg. 128-134 (Jun 2018) ISSN: 1873-6254 [Electronic] Netherlands
PMID29486176 (Publication Type: Journal Article)
CopyrightCopyright © 2018 Elsevier B.V. All rights reserved.
Topics
  • Adult
  • Aged
  • Aged, 80 and over
  • Animals
  • Bile Duct Neoplasms (diagnostic imaging, epidemiology, parasitology)
  • Cholangiocarcinoma (diagnostic imaging, epidemiology, parasitology)
  • Cross-Sectional Studies
  • Endemic Diseases (statistics & numerical data)
  • Female
  • Humans
  • Laos (epidemiology)
  • Male
  • Middle Aged
  • Opisthorchiasis (complications, parasitology)
  • Opisthorchis
  • Prevalence
  • Rivers (parasitology)
  • Ultrasonography (methods, statistics & numerical data)
  • Young Adult

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