Hepatitis E virus (HEV)
infection in immunocompromised patients often results in distinct outcome, compared to the
infection in general population. This study aimed to investigate the prevalence, potential risk factors, and clinical features of HEV
infection among HIV patients treated with antiretroviral
therapy (ART) in Yunnan province, China. A total of 770 HIV-infected patients between May 2015 and February 2016 were enrolled in Yunnan, China. All patients received ART. All plasma samples were tested for anti-HEV
IgG, anti-HEV
IgM antibodies using ELISA kits, and HEV
RNA by real-time qRT-PCR. Association between anti-HEV antibody positivity and demographic, clinical and laboratory measures was assessed in univariate and multivariate logistic regression models. Of the 770 HIV-infected patients, 342 patients (44.42%) were anti-HEV
IgG antibody positive, and six patients (0.78%) were anti-HEV
IgM antibody positive. None of the patients was HEV
RNA positive, as tested in our assays. We found that age, gender, CD4 cell count, WHO stage, marital status, and total
cholesterol levels were associated with HEV
infection. We report a high seroprevalence rate and several potential risk factors of HEV
infection in a large HIV cohort from Yunnan province in China. Further research on identification of the circulating HEV strains and the clinical outcome of this patient population is required.