PROGRESSION OF RETINAL ISCHEMIA IN A CASE OF MACULAR TELANGIECTASIA TYPE 1 AFTER RANIBIZUMAB INJECTION: OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY FINDINGS.

Abstract

PURPOSE:

To describe a case of a 68-year-old man with macular telangiectasia (MacTel) Type 1 in the right eye, showing an increase in capillary ischemia after intravitreal ranibizumab.

METHODS:

The patient underwent complete ophthalmologic evaluation, including best-corrected visual acuity, intraocular pressure, anterior segment and fundus examination, optical coherence tomography (OCT), and OCT angiography at baseline and on each visit. Fluorescein angiography was performed at baseline. The patient was followed up on monthly bases for 22 months.

RESULTS:

The patient presented a best-corrected visual acuity of 20/80 in the right eye and of 20/25 in the left eye at baseline. In the right eye, the fluorescein angiography images showed perifoveal capillary ectasia, late-frames dye leakage, and enlargement of the foveal avascular zone. The OCT showed intraretinal pseudocysts and microaneurysms, and the OCT angiography showed vascular rarefaction, capillary dropout, and capillary ectasia of the superficial plexus. After 16 months of follow-up and four ranibizumab injections, the best-corrected visual acuity was 20/60, and the OCT angiography disclosed a further enlargement of the foveal avascular zone area and increased capillary obliteration in the perifoveal nasal area.

CONCLUSION:

Optical coherence tomography angiography may represent an indispensable diagnostic technique, complementary to traditional imaging, in the evaluation of the effects of anti-vascular endothelial growth factor therapy in patients with MacTel Type 1.

• Authors: Massimo Lorusso, Roberta Zito, Eleni Nikolopoulou, Luisa Micelli Ferrari, Maria Vittoria Cicinelli, Giuseppe Querques, Tommaso Micelli Ferrari
• Journal: Retinal cases & brief reports (Retin Cases Brief Rep) Vol. 14 Issue 4 Pg. 372-376 ( 2020) ISSN: 1937-1578 [Electronic] United States
• PMID: 29443804 (Publication Type: Case Reports, Journal Article)

Chemical References

• Angiogenesis Inhibitors
• VEGFA protein, human
• Vascular Endothelial Growth Factor A
• Ranibizumab

Topics

• Aged
• Angiogenesis Inhibitors (adverse effects, therapeutic use)
• Disease Progression
• Fluorescein Angiography
• Follow-Up Studies
• Humans
• Intraocular Pressure (physiology)
• Intravitreal Injections
• Ischemia (chemically induced, diagnosis)
• Male
• Ranibizumab (adverse effects, therapeutic use)
• Retinal Vessels (drug effects, pathology)
• Telangiectasia, Hereditary Hemorrhagic (diagnosis, drug therapy)
• Tomography, Optical Coherence
• Vascular Endothelial Growth Factor A (antagonists & inhibitors)
• Visual Acuity (physiology)