A Synthetic Approach for the Rapid Preparation of BODIPY Conjugates and their use in Imaging of Cellular Drug Uptake and Distribution.

Abstract

A solid-phase synthetic (SPS) method was developed for the preparation of BODIPY-labeled bioactive compounds that allows for fast and simple synthesis of conjugates for use in fluorescent microscopy. The approach was used to visualize cellular uptake and distribution of cytotoxic triterpenes in cancer cells.

• Authors: Sona Krajcovicova, Jarmila Stankova, Petr Dzubak, Marian Hajduch, Miroslav Soural, Milan Urban
• Journal: Chemistry (Weinheim an der Bergstrasse, Germany) (Chemistry) Vol. 24 Issue 19 Pg. 4957-4966 (Apr 03 2018) ISSN: 1521-3765 [Electronic] Germany
• PMID: 29411907 (Publication Type: Journal Article)
• Copyright: © 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Chemical References

• 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene
• Boron Compounds
• Triterpenes

Topics

• Biological Transport
• Boron Compounds (chemical synthesis, chemistry)
• Humans
• Microscopy, Fluorescence
• Tissue Distribution (physiology)
• Triterpenes (analysis)