Acquired amegakaryocytic thrombocytopenia and red cell aplasia in a patient with thymoma progressing to aplastic anemia successfully treated with allogenic stem cell transplantation.
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| Abstract |
Association of pure red-cell aplasia with thymoma is well documented. However, acquired amegakaryocytic thrombocytopenia (AAMT) has been rarely associated with thymoma with only five reported cases in literature. We report a patient with thymoma complicated by pure red cell aplasia (PRCA) and AAMT who progressed to develop aplastic anemia (AA). The patient was refractory to 10-months of immunosuppressive therapy with cyclosporine, prednisone, and antithymocyte globulin. She was eventually treated with allogeneic stem cell transplantation (allo-SCT). On Day +323 the patient continues to be transfusion-independent. This case illustrates how in patients with thymoma and AAMT may herald development of AA. This is also the first report of a patient with AAMT progressing to thymoma-associated AA being successfully treated with allo-SCT. The successful outcome suggests allo-SCT as a feasible option similar to other AA patients.
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| Authors | Aron Simkins, Abhishek Maiti, Nicholas J Short, Nitin Jain, Uday Popat, Keyur P Patel, Thein H Oo |
| Journal | Hematology/oncology and stem cell therapy (Hematol Oncol Stem Cell Ther) Vol. 12 Issue 2 Pg. 115-118 (Jun 2019) ISSN: 2589-0646 [Electronic] Saudi Arabia |
| PMID | 29409729 (Publication Type: Case Reports, Journal Article) |
| Copyright | Copyright © 2018 King Faisal Specialist Hospital & Research Centre. Published by Elsevier Ltd. All rights reserved. |
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