Quantifying Effect of Onabotulinum Toxin A on Passive Muscle Stiffness in Children with Cerebral Palsy Using Ultrasound Shear Wave Elastography.

Abstract

OBJECTIVE:

A pilot study was conducted to longitudinally quantify effect of onabotulinum toxin A (BoNT-A) on passive muscle properties in children with cerebral palsy using ultrasound shear wave elastography.

DESIGN:

This was a prospective longitudinal cohort study.

RESULTS:

Between 1 and 3 mos post-BoNT-A, a significant improvement in the shear modulus of the lateral gastrocnemius was found at 10-degrees plantar flexion (PF) (-7.57 [-10.98, -5.07], P = 0.02) and 0-degrees PF (-14.74 [-18.21, -9.38], P = 0.03). There was a notable, but nonsignificant, difference in shear modulus at 20-degrees PF, 10-degrees PF, and 0-degrees PF between pre-BoNT-A and 1 mo post-BoNT-A. Pre-BoNT-A shear modulus was not significantly different from 3 mos post-BoNT-A at all foot positions. No significant differences in ankle passive range of motion or spasticity were found.

CONCLUSION:

Despite no significant change in ankle range of motion or spasticity, shear wave elastography was able to detect a difference in lateral gastrocnemius passive muscle properties in children with cerebral palsy after BoNT-A injections. The difference in passive muscle properties resolved by 3 mos post-BoNT-A.

• Authors: Joline E Brandenburg, Sarah F Eby, Pengfei Song, William R Bamlet, Gary C Sieck, Kai-Nan An
• Journal: American journal of physical medicine & rehabilitation (Am J Phys Med Rehabil) Vol. 97 Issue 7 Pg. 500-506 (07 2018) ISSN: 1537-7385 [Electronic] United States
• PMID: 29406405 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)

Chemical References

• Botulinum Toxins, Type A

Topics

• Botulinum Toxins, Type A (administration & dosage)
• Cerebral Palsy (diagnostic imaging, drug therapy)
• Child
• Elasticity Imaging Techniques (methods)
• Female
• Humans
• Longitudinal Studies
• Male
• Muscle Spasticity (diagnostic imaging, drug therapy)
• Muscle, Skeletal (diagnostic imaging, drug effects)
• Pilot Projects
• Prospective Studies
• Range of Motion, Articular (physiology)