[A Case of Cecal Cancer with Para-Aortic Lymph Node Metastasis and Peritoneum Dissemination Treated with Curative Resection after mFOLFOX6 plus Panitumumab Chemotherapy].

Abstract

A 67-year-old woman was diagnosed with cecal cancer, para-aortic lymph node metastasis, peritoneum dissemination, and left breast cancer. We administered mFOLFOX6 plus panitumumab for cecal cancer and an aromatase inhibitor for her breast cancer. She received 7 courses of systemic chemotherapy and showed a partial response. She additionally received 5 courses of mFOLFOX6 plus panitumumab. We performed ileocecal resection, sigmoidectomy, right oophorectomy, dissection of the para-aortic lymph nodes, and peritoneal dissemination. The histopathological findings revealed adenocarcinoma, ypT3, ypN0, ycM0, ypStage II (therapeutic effect Grade 2). One month later, she underwent an enforced left breast segmental resection and sentinel lymph node biopsy(0/2). The results of the pathological examination indicated no residual cancers (therapeutic effect Grade 3). The patient is now in good health and was administered S-1 as an outpatient.

• Authors: Kei Kimura, Masafumi Noda, Ayako Imada, Jihyung Song, Akihito Babaya, Michiko Hamanaka, Masayoshi Kobayashi, Kiyoshi Tsukamoto, Tomoki Yamano, Masataka Ikeda, Naohiro Tomita
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 44 Issue 12 Pg. 1293-1295 (Nov 2017) ISSN: 0385-0684 [Print] Japan
• PMID: 29394611 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antibodies, Monoclonal
• Organoplatinum Compounds
• Panitumumab
• Leucovorin
• Fluorouracil

Topics

• Aged
• Antibodies, Monoclonal (administration & dosage)
• Antineoplastic Combined Chemotherapy Protocols (administration & dosage, therapeutic use)
• Aorta (pathology, surgery)
• Cecal Neoplasms (drug therapy, pathology, surgery)
• Colectomy
• Female
• Fluorouracil (administration & dosage)
• Humans
• Leucovorin (administration & dosage)
• Lymphatic Metastasis
• Neoadjuvant Therapy
• Organoplatinum Compounds (administration & dosage)
• Panitumumab
• Peritoneal Neoplasms (drug therapy, secondary, surgery)