Role of dental hardware in oral cavity squamous cell carcinoma in the low-risk nonsmoker nondrinker population.

Abstract

BACKGROUND:

Oral cavity squamous cell carcinoma (SCC) arising in nonsmokers and nondrinkers remains poorly characterized. We hypothesized that these patients had prior exposure to metallic dental hardware.

METHODS:

We utilized a questionnaire querying the lifetime oral health status of 54 patients. Demographics and extensive oral health history were collected.

RESULTS:

The majority of patients (74%) had prior exposure to metallic dental hardware. The younger population with almost exclusively oral tongue cancer had a high prevalence of metallic orthodontic braces (40%) within 15 years before diagnosis. In the 51+ year age group, 82% had crowns, dental implants, and/or dentures with metallic elements.

CONCLUSION:

Exposure to metallic dental hardware has increased in the past few decades given the rise of orthodontic braces and older adults retaining more teeth. Although this study does not prove a causal relationship between oral cavity SCC and dental hardware, this is a step toward identifying and investigating their role.

• Authors: Jessica A Yesensky, Rifat Hasina, Kristen E Wroblewski, Joseph Bellairs, Zhen Gooi, Vassiliki Saloura, Nicole A Cipriani, Everett E Vokes, Louis G Portugal, Tanguy Y Seiwert, Elizabeth D Blair, Nishant Agrawal
• Journal: Head & neck (Head Neck) Vol. 40 Issue 4 Pg. 784-792 (04 2018) ISSN: 1097-0347 [Electronic] United States
• PMID: 29356169 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2018 Wiley Periodicals, Inc.

Chemical References

• Dental Alloys
• Metals

Topics

• Adolescent
• Adult
• Age Factors
• Aged
• Alcohol Drinking
• Cohort Studies
• Confidence Intervals
• Dental Alloys (adverse effects)
• Female
• Humans
• Incidence
• Life Style
• Male
• Metals (adverse effects)
• Middle Aged
• Mouth Neoplasms (epidemiology, etiology, physiopathology)
• Non-Smokers
• Oral Health
• Orthodontic Appliances (adverse effects)
• Prognosis
• Retrospective Studies
• Risk Factors
• Sex Factors
• Squamous Cell Carcinoma of Head and Neck (epidemiology, etiology, physiopathology)
• Surveys and Questionnaires
• Tongue Neoplasms (epidemiology, etiology, physiopathology)
• United States
• Young Adult