Suppressor T cell changes in active multiple sclerosis: analysis with three different monoclonal antibodies.

Abstract

This study demonstrates a significant reduction in the number of both total T cells and suppressor T cells identified by monoclonal antibodies in multiple sclerosis patients in acute relapse but not in those in remission. The reduction in the number of suppressor T cells was shown by all three monoclonal antibodies used but was most clearly demonstrated using Leu 2a rather than either OKT 8 or OKT 5. These findings suggest that the choice of monoclonal antibody used in a study of suppressor T cell numbers will influence the results and may help explain the lack of agreement in previous studies.

• Authors: A J Thompson, J Brazil, E A Martin, M Hutchinson, C A Whelan, C Feighery
• Journal: Journal of neurology, neurosurgery, and psychiatry (J Neurol Neurosurg Psychiatry) Vol. 48 Issue 10 Pg. 1062-4 (Oct 1985) ISSN: 0022-3050 [Print] England
• PMID: 2932538 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antibodies, Monoclonal

Topics

• Antibodies, Monoclonal
• Humans
• Leukocyte Count
• Multiple Sclerosis (blood)
• T-Lymphocytes (immunology)
• T-Lymphocytes, Regulatory