[Outcomes of alternative donor allogeneic hematopoietic stem cell transplantation for Fanconi anemia: a five cases report].

Abstract

Five patients with Fanconi anemia who received hematopoietic cell transplantation were retrospectively analyzed. The conditioning regimens included fludarabine, cyclophosphamide and anti-thymocyte globulin. Two patients received both bone marrow and peripheral blood stem cells as the source of stem cell grafts from haploidentical matched related donors, while the others received peripheral blood stem cells from unrelated donors. All patients tolerated well and reached hematopoietic reconstitution. One patient died of intracranial infection. During follow-up, 4 patients survived independent of transfusion with full donor chimerism.

• Authors: W J Wang, Y Q Sun, F F Tang, T T Han, X D Mo, J Z Wang, X H Zhang, X J Huang, L P Xu
• Journal: Zhonghua nei ke za zhi (Zhonghua Nei Ke Za Zhi) Vol. 57 Issue 1 Pg. 54-56 (Jan 01 2018) ISSN: 0578-1426 [Print] China
• PMID: 29325312 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antilymphocyte Serum
• Cyclophosphamide
• Vidarabine
• fludarabine

Topics

• Antilymphocyte Serum (administration & dosage, therapeutic use)
• Bone Marrow
• Cyclophosphamide (administration & dosage, therapeutic use)
• Fanconi Anemia (therapy)
• Graft vs Host Disease (prevention & control)
• Hematopoietic Stem Cell Transplantation
• Humans
• Retrospective Studies
• Transplantation Conditioning
• Treatment Outcome
• Unrelated Donors
• Vidarabine (analogs & derivatives)