Health Benefits of an Innovative Exercise Program for Mitochondrial Disorders.

Abstract

PURPOSE:

We determined the effects of an innovative 8-wk exercise intervention (aerobic, resistance, and inspiratory muscle training) for patients with mitochondrial disease.

METHODS:

Several end points were assessed in 12 patients (19-59 yr, 4 women) at pretraining, posttraining, and after 4-wk detraining: aerobic power, muscle strength/power and maximal inspiratory pressure (main end points), ability to perform activities of daily living, body composition, quality of life, and blood myokines (secondary end points).

RESULTS:

The program was safe, with patients' adherence being 94% ± 5%. A significant time effect was found for virtually all main end points (P ≤ 0.004), indicating a training improvement. Similar findings (P ≤ 0.003) were found for activities of daily living tests, total/trunk/leg lean mass, total fat mass, femoral fracture risk, and general health perception. No differences were found for blood myokines, except for an acute exertional increase in interleukin 8 at posttraining/detraining (P = 0.002) and in fatty acid binding protein 3 at detraining (P = 0.002).

CONCLUSIONS:

An intervention including novel exercises for mitochondrial disease patients (e.g., inspiratory muscle training) produced benefits in numerous indicators of physical capacity and induced a previously unreported shift toward a healthier body composition phenotype.

• Authors: Carmen Fiuza-Luces, Jorge Díez-Bermejo, Miguel Fernández-DE LA Torre, Gabriel Rodríguez-Romo, Paz Sanz-Ayán, Aitor Delmiro, Diego Munguía-Izquierdo, Irene Rodríguez-Gómez, Ignacio Ara, Cristina Domínguez-González, Joaquín Arenas, Miguel A Martín, Alejandro Lucia, María Morán
• Journal: Medicine and science in sports and exercise (Med Sci Sports Exerc) Vol. 50 Issue 6 Pg. 1142-1151 (06 2018) ISSN: 1530-0315 [Electronic] United States
• PMID: 29315169 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Topics

• Activities of Daily Living
• Adult
• Body Composition
• Exercise Therapy
• Female
• Humans
• Male
• Middle Aged
• Mitochondrial Diseases (therapy)
• Muscle Strength
• Physical Functional Performance
• Quality of Life
• Young Adult