Protein Kinase CK2: An Emerging Regulator of Immunity.

Abstract

Although it has historically been studied in the context of cancer, recent literature has highlighted the importance of the highly conserved serine/threonine kinase casein kinase II (CK2) in inflammatory disorders. Most strikingly, CK2 is a major regulator of the Th17-Treg axis relevant to many T cell-driven autoimmune disorders including multiple sclerosis (MS).

• Authors: Sara A Gibson, Etty N Benveniste
• Journal: Trends in immunology (Trends Immunol) Vol. 39 Issue 2 Pg. 82-85 (02 2018) ISSN: 1471-4981 [Electronic] England
• PMID: 29307449 (Publication Type: Journal Article)
• Copyright: Copyright © 2017 Elsevier Ltd. All rights reserved.

Chemical References

• Naphthyridines
• Phenazines
• silmitasertib
• Casein Kinase II
• Emodin

Topics

• Animals
• Autoimmune Diseases (drug therapy, immunology)
• Casein Kinase II (antagonists & inhibitors, immunology)
• Clinical Trials as Topic
• Emodin (metabolism)
• Humans
• Immunity
• Immunomodulation
• Inflammation (immunology)
• Mice
• Molecular Targeted Therapy
• Multiple Sclerosis (immunology)
• Naphthyridines (pharmacology)
• Neoplasms (drug therapy, immunology)
• Phenazines
• Signal Transduction
• T-Lymphocytes, Regulatory (immunology)
• Th17 Cells (immunology)