Randomized controlled clinical trial on the antiseptic efficacy of polihexanide 0.04% on acute traumatic wounds.

Prevention of wound infections is a challenge in clinical practice. The aim of this study was to assess the efficacy of polyhexamethylene biguanide (PHMB, polihexanide) 0.04% on acute traumatic wounds. It was a randomized, double-blind, placebo-controlled prospective trial which included 61 patients. The polihexanide group showed a significant decrease in log10 colony-forming units (cfu) (P < 0.001) after 60 min treatment in comparison to baseline cfu, whereas the Ringer solution group did not show a significant change in cfu during 60 min treatment. Treatment of polihexanide 0.04% resulted in a significant reduction of bacterial load in acute traumatic wounds.
AuthorsB Payne, H-P Simmen, E Csuka, M Hintzpeter, S Pahl, F H H Brill
JournalThe Journal of hospital infection (J Hosp Infect) Vol. 98 Issue 4 Pg. 429-432 (Apr 2018) ISSN: 1532-2939 [Electronic] England
PMID29288775 (Publication Type: Journal Article, Randomized Controlled Trial)
CopyrightCopyright © 2017 The Healthcare Infection Society. Published by Elsevier Ltd. All rights reserved.
Chemical References
  • Anti-Infective Agents, Local
  • Biguanides
  • Placebos
  • polihexanide
  • Adult
  • Aged
  • Anti-Infective Agents, Local (administration & dosage)
  • Bacterial Load
  • Biguanides (administration & dosage)
  • Colony Count, Microbial
  • Double-Blind Method
  • Humans
  • Male
  • Middle Aged
  • Placebos (administration & dosage)
  • Prospective Studies
  • Treatment Outcome
  • Wound Infection (prevention & control)
  • Wounds and Injuries (complications)
  • Young Adult

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