Randomized controlled clinical trial on the antiseptic efficacy of polihexanide 0.04% on acute traumatic wounds.

Abstract

Prevention of wound infections is a challenge in clinical practice. The aim of this study was to assess the efficacy of polyhexamethylene biguanide (PHMB, polihexanide) 0.04% on acute traumatic wounds. It was a randomized, double-blind, placebo-controlled prospective trial which included 61 patients. The polihexanide group showed a significant decrease in log10 colony-forming units (cfu) (P < 0.001) after 60 min treatment in comparison to baseline cfu, whereas the Ringer solution group did not show a significant change in cfu during 60 min treatment. Treatment of polihexanide 0.04% resulted in a significant reduction of bacterial load in acute traumatic wounds.

• Authors: B Payne, H-P Simmen, E Csuka, M Hintzpeter, S Pahl, F H H Brill
• Journal: The Journal of hospital infection (J Hosp Infect) Vol. 98 Issue 4 Pg. 429-432 (Apr 2018) ISSN: 1532-2939 [Electronic] England
• PMID: 29288775 (Publication Type: Journal Article, Randomized Controlled Trial)
• Copyright: Copyright © 2017 The Healthcare Infection Society. Published by Elsevier Ltd. All rights reserved.

Chemical References

• Anti-Infective Agents, Local
• Biguanides
• Placebos
• polihexanide

Topics

• Adult
• Aged
• Anti-Infective Agents, Local (administration & dosage)
• Bacterial Load
• Biguanides (administration & dosage)
• Colony Count, Microbial
• Double-Blind Method
• Humans
• Male
• Middle Aged
• Placebos (administration & dosage)
• Prospective Studies
• Treatment Outcome
• Wound Infection (prevention & control)
• Wounds and Injuries (complications)
• Young Adult