Abstract | PURPOSE: METHODS AND MATERIALS: From 2007 through 2014, 343 EC patients who received definitive CRT with either PBT (n=132) or IMRT (n=211) were retrospectively analyzed. Survival, recurrence, and treatment toxicity were compared between groups. A Cox proportional hazards regression model was performed to test the association between patient/treatment variables and survival. RESULTS: Patient/treatment variables were overall well balanced, except for age and race. Compared with IMRT, PBT had significantly better overall survival (OS; P=.011), progression-free survival (PFS; P=.001), distant metastasis-free survival (DMFS; P=.031), as well as marginally better locoregional failure-free survival (LRFFS; P=.075). No significant differences in rates of treatment-related toxicities were observed between groups. On multivariate analysis, IMRT had worse OS (hazard ratio [HR] 1.454; P=.01), PFS (HR 1.562; P=.001), and LRFFS (HR 1.461; P=.041) than PBT. Subgroup analysis by clinical stage revealed considerably higher 5-year OS (34.6% vs 25.0%, P=.038) and PFS rates (33.5% vs 13.2%, P=.005) in the PBT group for patients with stage III disease. However, no significant intergroup differences in survival were identified for stage I/II patients. CONCLUSIONS: Compared with IMRT, PBT might be associated with improved OS, PFS, and LRFFS, especially in EC patients with locally advanced disease. These results need confirmation by prospective studies.
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Authors | Mian Xi, Cai Xu, Zhongxing Liao, Joe Y Chang, Daniel R Gomez, Melenda Jeter, James D Cox, Ritsuko Komaki, Reza Mehran, Mariela A Blum, Wayne L Hofstetter, Dipen M Maru, Manoop S Bhutani, Jeffrey H Lee, Brian Weston, Jaffer A Ajani, Steven H Lin |
Journal | International journal of radiation oncology, biology, physics
(Int J Radiat Oncol Biol Phys)
Vol. 99
Issue 3
Pg. 667-676
(11 01 2017)
ISSN: 1879-355X [Electronic] United States |
PMID | 29280461
(Publication Type: Comparative Study, Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2017 Elsevier Inc. All rights reserved. |
Topics |
- Aged
- Chemoradiotherapy
(adverse effects, methods)
- Disease-Free Survival
- Esophageal Neoplasms
(mortality, radiotherapy)
- Female
- Humans
- Male
- Middle Aged
- Proton Therapy
(adverse effects)
- Radiotherapy, Intensity-Modulated
(adverse effects)
- Regression Analysis
- Retrospective Studies
- Treatment Outcome
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