Clinical Analysis of Esophageal Stricture in Patients Treated with Intralesional Triamcinolone Injection after Endoscopic Submucosal Dissection for Superficial Esophageal Cancer.

Abstract

INTRODUCTION:

Endoscopic submucosal dissection (ESD) has been widely used in the resection of superficial esophageal cancers. Since its use has been extended to cases involving large esophageal tumors occupying nearly the whole or the whole circumference of the lumen, the occurrence of esophageal stricture has increased. Although endoscopic injection of triamcinolone (TA) is widely used for the prevention of postoperative stricture, a significant number of patients still develop stricture after TA injection therapy.

METHODS:

We performed a retrospective study to identify the clinical parameters that predispose post-ESD patients to esophageal stricture after TA injection therapy.

RESULTS:

A total of 207 patients who were diagnosed with superficial esophageal cancer and subsequently underwent ESD were enrolled in this study. Among these patients, 53 patients and 57 lesions bearing mucosal defects covering greater than two-thirds of the esophageal circumference after ESD were treated with TA injection therapy. The rate of esophageal stricture was found to be highest in cases involving mucosal defects that covered more than seven-eighths of the circumference.

CONCLUSION:

Endoscopic TA injection is not sufficient for preventing esophageal stricture in patients bearing mucosal defects covering more than seven-eighths of the esophageal circumference after ESD.

• Authors: Kazuki Okamoto, Shigenaga Matsui, Tomohiro Watanabe, Yutaka Asakuma, Yoriaki Komeda, Ayana Okamoto, Ishikawa Rei, Masashi Kono, Mitsunari Yamada, Tomoyuki Nagai, Tadaaki Arizumi, Kosuke Minaga, Ken Kamata, Kentaro Yamao, Mamoru Takenaka, Toshiharu Sakurai, Naoshi Nishida, Hiroshi Kashida, Takaaki Chikugo, Masatoshi Kudo
• Journal: Oncology (Oncology) Vol. 93 Suppl 1 Pg. 9-14 ( 2017) ISSN: 1423-0232 [Electronic] Switzerland
• PMID: 29258096 (Publication Type: Journal Article)
• Copyright: © 2017 S. Karger AG, Basel.

Chemical References

• Anti-Inflammatory Agents
• Triamcinolone

Topics

• Aged
• Anti-Inflammatory Agents (administration & dosage)
• Endoscopic Mucosal Resection (adverse effects, methods)
• Esophageal Neoplasms (drug therapy, surgery)
• Esophageal Stenosis (etiology, prevention & control)
• Female
• Humans
• Injections, Intralesional
• Male
• Retrospective Studies
• Triamcinolone (administration & dosage)