Abstract | BACKGROUND: The Arg213His (rs9282861) polymorphism of Sulfotransferase Family 1A Member 1 (SULT1A1) gene has been associated with risk of breast cancer in some epidemiological studies. Therefore, this systematic review and meta-analysis was conducted to evaluate the association of SULT1A1 Arg213His (rs9282861) polymorphism with susceptibility to breast cancer. STUDY DESIGN: A systematic review and meta-analysis. METHODS: A comprehensive literature search for eligible studies was conducted in PubMed, Elsevier, Science Direct, Scopus and Google Scholar databases up to Oct 5, 2017. Pooled odds ratios ( ORs) with their corresponding 95% confidence intervals (95% CIs) were used to evaluate the strength of the association using fixed effects models and random effects models. RESULTS: Twenty relevant case-control studies involving 11077 cases and 14798 controls were included in this meta-analysis. Overall, there was a significant association between the SULT1A1 Arg213His (rs9282861) polymorphism and risk of breast cancer in the allele mode (A vs. G: OR=1.117, 95% CI: 1.011, 1.233, P=0.029) and the homozygote model (AA vs. GG: OR=1.288, 95% CI: 1.036, 1.601, P=0.022). Subgroup analysis based on ethnicity suggested SULT1A1 Arg213His (rs9282861) polymorphism had a subtly increased breast cancer risk among Asian population, but not Caucasians. Further, subgroup analyses, significant associations were observed in hospital-based group, RFLP-PCR group, and high-quality studies subgroups. CONCLUSIONS: SULT1A1 Arg213His (rs9282861) polymorphism might be associated with breast cancer risk, especially among Asian population. Moreover, the SULT1A1 Arg213His polymorphism is of high clinical relevance by ethnicity and would be a useful marker to identify patients who are at higher risk for breast cancer.
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Authors | Mohammad Forat-Yazdi, Mohammadali Jafari, Saeed Kargar, Seyed Mojtaba Abolbaghaei, Rezvan Nasiri, Soudabeh Farahnak, Elnaz Foroughi, Hossein Neamatzadeh |
Journal | Journal of research in health sciences
(J Res Health Sci)
Vol. 17
Issue 4
Pg. e00396
(Oct 14 2017)
ISSN: 2228-7809 [Electronic] Iran |
PMID | 29233949
(Publication Type: Journal Article, Meta-Analysis, Review, Systematic Review)
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Chemical References |
- Arylsulfotransferase
- SULT1A1 protein, human
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Topics |
- Alleles
- Arylsulfotransferase
(genetics)
- Asian People
- Breast Neoplasms
(genetics)
- Female
- Genetic Predisposition to Disease
- Genotype
- Humans
- Polymorphism, Genetic
- White People
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