[Time Course of Changes in Visual Acuity After a Single Injection of Aflibercept or Ranibizumab in Neovascular Age-related Macular Degeneration - Analysis of Aggregated Real Life Data].

Abstract

Background Treatment of neovascular age-related macular degeneration (nvAMD) under real life conditions may differ from controlled prospective trials with respect to the number of injections and long term preservation of visual acuity. In many instances, intervals for controls and re-injection cannot be maintained as frequently as required. This case series examines actual intervals for control and re-injection visits, in order to estimate how prolonged intervals have an impact on momentary visual acuity and how long term visual outcome is affected. Patients/Material and Methods Retrospective case series of 1,324 eyes with nvAMD, treated with a total of 8,150 ranibizumab injections (according to the PRN regimen) or 1,725 aflibercept injections (according to a fixed regimen), during the observation period of up to 3 years. The evaluation covered the time interval between visits, impact of this on the course of visual acuity, as well as the number of injections throughout treatment. Results Planned intervals of 4 or 8 weeks between visits were more often exceeded in the PRN regimen than with the fixed regimen. Visual acuity does not peak after 4 weeks, but only between 6 and 8 weeks. No statistically significant difference between aflibercept and ranibizumab was found. If the mean interval for re-injection was maintained at 4 - 6 weeks, this gave the greatest gains in visual acuity at end of years 1 and 2, respectively. Any prolongation of these intervals was accompanied by worse long term visual acuity. The fixed regimen is associated with consistently briefer re-treatment intervals during years 2 and 3, than with the PRN regimen. Conclusion Our data point to the importance of frequent controls accompanied by timely retreatment, as these have a major impact on visual outcome. It therefore appears to be more important to choose a treatment plan that facilitates frequent re-injections than to select either of the two compounds.

• Authors: Robert G H Wilke, Robert Patrick Finger, Helmut G Sachs
• Journal: Klinische Monatsblatter fur Augenheilkunde (Klin Monbl Augenheilkd) Vol. 234 Issue 12 Pg. 1508-1514 (Dec 2017) ISSN: 1439-3999 [Electronic] Germany
• Vernacular Title: Der zeitliche Verlauf der Visusentwicklung nach einer Injektion von Aflibercept oder Ranibizumab bei der neovaskulären altersbedingten Makuladegeneration.
• PMID: 29232758 (Publication Type: Comparative Study, Journal Article)
• Copyright: Georg Thieme Verlag KG Stuttgart · New York.

Chemical References

• Recombinant Fusion Proteins
• aflibercept
• Receptors, Vascular Endothelial Growth Factor
• Ranibizumab

Topics

• Aged
• Aged, 80 and over
• Cohort Studies
• Drug Administration Schedule
• Female
• Follow-Up Studies
• Germany
• Humans
• Intravitreal Injections
• Male
• Ranibizumab (therapeutic use)
• Receptors, Vascular Endothelial Growth Factor (therapeutic use)
• Recombinant Fusion Proteins (therapeutic use)
• Retrospective Studies
• Visual Acuity (drug effects)
• Wet Macular Degeneration (drug therapy)