Abstract |
Genome editing using clustered regularly interspersed short palindromic repeats (CRISPR) and CRISPR-associated proteins offers the potential to facilitate safe and effective treatment of genetic diseases refractory to other types of intervention. Here, we identify some of the major challenges for clinicians, regulators, and human research ethics committees in the clinical translation of CRISPR-mediated somatic cell therapy.
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Authors | Dianne Nicol, Lisa Eckstein, Michael Morrison, Jacob S Sherkow, Margaret Otlowski, Tess Whitton, Tania Bubela, Kathryn P Burdon, Don Chalmers, Sarah Chan, Jac Charlesworth, Christine Critchley, Merlin Crossley, Sheryl de Lacey, Joanne L Dickinson, Alex W Hewitt, Joanne Kamens, Kazuto Kato, Erika Kleiderman, Satoshi Kodama, John Liddicoat, David A Mackey, Ainsley J Newson, Jane Nielsen, Jennifer K Wagner, Rebekah E McWhirter |
Journal | Genome medicine
(Genome Med)
Vol. 9
Issue 1
Pg. 85
(09 25 2017)
ISSN: 1756-994X [Electronic] England |
PMID | 28946923
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Topics |
- Biomedical Technology
- Cell- and Tissue-Based Therapy
(economics, ethics)
- Clinical Medicine
(economics, legislation & jurisprudence, trends)
- Clustered Regularly Interspaced Short Palindromic Repeats
- Humans
- Intellectual Property
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