Abstract | BACKGROUND: METHODS: We performed a systematic review of randomised trials using network meta-analysis (NMA), searching the following databases until 5 July 2016: Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, EMBASE, CINAHL, AMED, Web of Science, and four other databases. We included studies with adult people with stroke. We compared any kind of active tDCS (anodal, cathodal, or dual, that is applying anodal and cathodal tDCS concurrently) regarding improvement of our primary outcome of ADL capacity, versus control, after stroke. PROSPERO ID: CRD42016042055. RESULTS: We included 26 studies with 754 participants. Our NMA showed evidence of an effect of cathodal tDCS in improving our primary outcome, that of ADL capacity (standardized mean difference, SMD = 0.42; 95% CI 0.14 to 0.70). tDCS did not improve our secondary outcome, that of arm function, measured by the Fugl-Meyer upper extremity assessment (FM-UE). There was no difference in safety between tDCS and its control interventions, measured by the number of dropouts and adverse events. CONCLUSION: Comparing different forms of tDCS shows that cathodal tDCS is the most promising treatment option to improve ADL capacity in people with stroke.
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Authors | Bernhard Elsner, Gert Kwakkel, Joachim Kugler, Jan Mehrholz |
Journal | Journal of neuroengineering and rehabilitation
(J Neuroeng Rehabil)
Vol. 14
Issue 1
Pg. 95
(09 13 2017)
ISSN: 1743-0003 [Electronic] England |
PMID | 28903772
(Publication Type: Journal Article, Meta-Analysis, Review, Systematic Review)
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Topics |
- Activities of Daily Living
- Arm
(physiopathology)
- Humans
- Network Meta-Analysis
- Randomized Controlled Trials as Topic
- Recovery of Function
- Stroke Rehabilitation
(instrumentation, methods)
- Transcranial Direct Current Stimulation
(methods)
- Treatment Outcome
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