Mantle Cell Lymphoma Presenting with Acute Bilateral Ophthalmoplegia.

Abstract

A 72-year-old woman presented with acute onset of double vision, bilateral complete blepharoptosis, and nearly complete ophthalmoplegia. Orbital and brain magnetic resonance imaging were normal. Further investigation revealed bicytopenia with hepatosplenomegaly. Liver biopsy revealed mantle cell lymphoma. Cytology later showed the presence of mantle cells in cerebrospinal fluid analysis. Her ophthalmoplegia improved from her first cycle of systemic and intrathecal chemotherapy. To the best of our knowledge, this is the second case in the literature of mantle cell lymphoma with central nervous system involvement presenting with ophthalmoplegia. This symptom should be considered one of the initial signs of mantle cell lymphoma.

• Authors: Yaran Koban, Hatice Özlece, Orhan Ayar, Mustafa Koç, Hüseyin Çelik, Zeliha Yazar, Ayşe Burcu
• Journal: Turkish journal of ophthalmology (Turk J Ophthalmol) Vol. 47 Issue 4 Pg. 235-237 (Aug 2017) ISSN: 2149-8695 [Print] Turkey
• PMID: 28845330 (Publication Type: Journal Article)