Abstract |
Inflammatory elements and genetics have major roles in febrile seizures (FS) pathogenesis. Seventy patients were enrolled and compared with 139 controls. The allele and genotype frequency of the IL-2 gene at -330 and +166 positions and the IFN-γ at +874 position were determined. A significant positive association with GG genotype at position -330 in the patient group was found (P=0.003). Further, a positive association was detected in simple and complex FS groups at the same position (P=0.03, P=0.004). IL-2 GT haplotype was significantly more common in the patients compared to controls (P=0.0008). Higher frequency of GT haplotype was detected in simple FS patients in comparison to controls (P=0.0003). Contrary, IL-2 TG haplotype frequency was lower in complex FS group (P=0.005). Overrepresentation of certain alleles, genotypes and haplotypes in IL-2 gene in FS patients could predispose individuals to this disease.
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Authors | Amin Shahrokhi, Ameneh Zare-Shahabadi, Mohammad Naeimi Poor, Firouzeh Sajedi, Samaneh Soltani, Samaneh Zoghi, Reza Shervin Badv, Mahmoud Reza Ashrafi, Nima Rezaei |
Journal | Acta medica Iranica
(Acta Med Iran)
Vol. 55
Issue 6
Pg. 354-359
(Jun 2017)
ISSN: 1735-9694 [Electronic] Iran |
PMID | 28843235
(Publication Type: Journal Article)
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Chemical References |
- Interleukin-2
- Interferon-gamma
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Topics |
- Alleles
- Case-Control Studies
- Child
- Child, Preschool
- Female
- Gene Frequency
- Genetic Predisposition to Disease
- Genotype
- Haplotypes
- Humans
- Infant
- Interferon-gamma
(genetics)
- Interleukin-2
(genetics)
- Male
- Polymorphism, Single Nucleotide
- Seizures, Febrile
(genetics)
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