Abstract | BACKGROUND:
Chemoradiotherapy is the standard treatment for locally advanced non-small cell lung cancer (NSCLC); however, it is disputed whether this treatment is suitable for patients aged ≥75. This study was conducted to determine the maximum tolerated dose (MTD) of pemetrexed for use in concurrent radiotherapy for elderly patients with locally advanced non-squamous NSCLC. METHODS: The eligibility criteria were as follows: aged ≥75 with inoperable stage IIIA or IIIB non-squamous NSCLC, no history of chemotherapy or radiotherapy, a performance status of 0 or 1, and adequate organ function. The patients were scheduled to receive pemetrexed on days 1, 22, 43, and 64 with concurrent once daily thoracic radiotherapy (60 Gy). The initial pemetrexed dose was 400 (level 1), and it was planned to increase the dose to 500 mg/m2 (level 2). RESULTS: CONCLUSIONS:
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Authors | Shinnosuke Takemoto, Yoichi Nakamura, Minoru Fukuda, Hiroaki Senju, Hiroshi Gyotoku, Hirokazu Taniguchi, Midori Shimada, Takaya Ikeda, Hiroyuki Yamaguchi, Katsumi Nakatomi, Nobuyuki Hayashi, Hiroshi Soda, Hiroshi Mukae |
Journal | Thoracic cancer
(Thorac Cancer)
Vol. 8
Issue 6
Pg. 577-581
(11 2017)
ISSN: 1759-7714 [Electronic] Singapore |
PMID | 28771961
(Publication Type: Clinical Trial, Phase I, Journal Article)
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Copyright | © 2017 The Authors. Thoracic Cancer published by China Lung Oncology Group and John Wiley & Sons Australia, Ltd. |
Chemical References |
- Antineoplastic Agents
- Pemetrexed
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Topics |
- Aged
- Antineoplastic Agents
(administration & dosage, adverse effects)
- Carcinoma, Non-Small-Cell Lung
(pathology, therapy)
- Chemoradiotherapy
- Drug Administration Schedule
- Humans
- Lung Neoplasms
(pathology, therapy)
- Male
- Maximum Tolerated Dose
- Neoplasm Staging
- Pemetrexed
(administration & dosage, adverse effects)
- Treatment Outcome
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