Effects of aqueous extract of Arctium lappa L. roots on serum lipid metabolism.

Abstract	Objective To identify potential genes that may be involved in lipid metabolism in rats after treatment with aqueous extract of Arctium lappa L (burdock). Methods Rats were randomly divided into six groups: (i) control (standard diet); (ii) model group (high-fat diet only); (iii) high-fat diet and low-dose aqueous burdock root extract (2 g/kg); (iv) high-fat diet and moderate-dose aqueous burdock root extract (4 g/kg); (v) high-fat diet and high-dose aqueous burdock root extract (8 g/kg); and (vi) a positive control group exposed to a high-fat diet and simvastatin (10 mg/kg). Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis was performed to find the potential candidate genes involved in the modulation of blood lipids by treatment with aqueous burdock root extract. Results Burdock root extract reduced body weight and cholesterol levels in rats. KEGG analysis revealed 113 genes that were involved in metabolic pathways. Of these, 27 potential genes associated with blood lipid metabolism were identified. Conclusions Aqueous extract of burdock root reduced body weight and cholesterol in rats, possibly by modulating the differential expression of genes.
Authors	Bo Hou, Wencheng Wang, Hui Gao, Shanglang Cai, Chunbo Wang
Journal	The Journal of international medical research (J Int Med Res) Vol. 46 Issue 1 Pg. 158-167 (Jan 2018) ISSN: 1473-2300 [Electronic] England
PMID	28758851 (Publication Type: Journal Article)
Chemical References	Cholesterol, HDL Cholesterol, LDL Hypolipidemic Agents Plant Extracts Solvents Triglycerides Water Simvastatin
Topics	Animals Arctium (chemistry) Body Weight (drug effects) Cholesterol, HDL (blood) Cholesterol, LDL (blood) Diet, High-Fat Encyclopedias as Topic Gene Expression Profiling Gene Expression Regulation Gene Ontology Hypolipidemic Agents (chemistry, pharmacology) Lipid Metabolism (drug effects, genetics) Male Molecular Sequence Annotation Plant Extracts (chemistry, pharmacology) Plant Roots (chemistry) Rats Rats, Sprague-Dawley Simvastatin (pharmacology) Solvents (chemistry) Triglycerides (blood) Water (chemistry)

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