Growth and morbidity of extremely preterm infants after early full enteral nutrition.

Abstract

OBJECTIVES:

To evaluate feasibility and consequences of accelerated feeding advancement on short-term outcomes in extremely low gestational age neonates (ELGANs) who stayed in our institution for >28 days.

METHODS:

Retrospective single-centre cohort analysis covering the years 2011-2013. Data are presented as median (IQR).

RESULTS:

Infants '(n=77) birth weight was 745 (640 to 960) g and gestational age at birth 26.7 (25.1 to 27.4) weeks. Full enteral feeds were attained by postnatal day 7 (5 to 11). Weight gain from birth to discharge was 14.3 (13.3 to 16.1) g/kg/day, change in SD score for weight -0.03 (-0.55 to 0.46) and 0.09 (-0.78 and 0.82) for head circumference. Rates of necrotising enterocolitis and spontaneous intestinal perforation in all ELGANs admitted during the study period were 3.1% and 9.4%, respectively.

CONCLUSIONS:

This cohort of ELGANs showed good weight gain and head growth after early full enteral nutrition. The impact of this feeding practice on neonatal morbidity and long-term outcome remains to be tested in adequately powered randomised trials.

• Authors: Christoph Maas, Axel R Franz, Stefanie von Krogh, Jörg Arand, Christian F Poets
• Journal: Archives of disease in childhood. Fetal and neonatal edition (Arch Dis Child Fetal Neonatal Ed) Vol. 103 Issue 1 Pg. F79-F81 (Jan 2018) ISSN: 1468-2052 [Electronic] England
• PMID: 28733478 (Publication Type: Journal Article)
• Copyright: © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

Topics

• Enteral Nutrition (adverse effects, methods, statistics & numerical data)
• Enterocolitis, Necrotizing (etiology, prevention & control)
• Female
• Germany (epidemiology)
• Gestational Age
• Humans
• Infant, Extremely Premature (growth & development)
• Infant, Newborn
• Infant, Premature, Diseases (epidemiology, therapy)
• Infant, Very Low Birth Weight (growth & development)
• Intestinal Perforation (etiology, prevention & control)
• Male
• Outcome and Process Assessment, Health Care
• Patient Discharge (statistics & numerical data)
• Retrospective Studies
• Time-to-Treatment
• Weight Gain