Primary Intra-aortic Epstein-Barr Virus-Positive Large B-Cell Lymphoma Presenting as Aortic Mural Thrombosis: An Entity Distinct From Intravascular Large B-Cell Lymphoma.

Abstract

Intravascular selective growth of neoplastic B lymphocytes is a characteristic finding of intravascular large B-cell lymphoma (IVLBCL). However, because neoplastic B cells of IVLBCL grow merely in the lumina of capillaries or small vessels, primary IVLBCL of the great vessels is considered exceptional. To our knowledge, only 2 primary B-cell lymphomas in the lumina of the vena cava have been reported. However, there has been no report of primary B-cell lymphoma with intra-aortic growth. We describe a novel manifestation of primary Epstein-Barr virus-positive large B-cell lymphoma mainly affecting the lumina of the aorta and its major branches in a 76-year-old man. He had a long-term fever that was refractory to antibiotics and aortic mural thrombosis with visceral embolization. Because he had no detectable mass suggesting a malignancy, it was difficult to diagnose while he was alive. He died without anticancer treatment, and the confirmed diagnosis was made at autopsy.

• Authors: Ryuta Nakao, Aki Sakashita, Atsushi Omoto, Osamu Sato, Yoko Hino, Akio Yanagisawa, Yoji Urata
• Journal: International journal of surgical pathology (Int J Surg Pathol) Vol. 25 Issue 8 Pg. 727-731 (Dec 2017) ISSN: 1940-2465 [Electronic] United States
• PMID: 28697692 (Publication Type: Case Reports, Journal Article)

Topics

• Aged
• Aorta (pathology)
• Epstein-Barr Virus Infections (complications)
• Herpesvirus 4, Human
• Humans
• Lymphoma, Large B-Cell, Diffuse (pathology, virology)
• Male
• Thrombosis (etiology)
• Vascular Neoplasms (pathology, virology)