A High HASBLED Score Identifies Poor Warfarin Control in Patients Treated for Non-Valvular Atrial Fibrillation in Australia and Singapore.

Abstract

Warfarin reduces stroke risk in atrial fibrillation (AF) patients. The quality of warfarin control, measured by time in therapeutic range (TTR), impacts outcome and adverse events. One tool evaluating risk of adverse events and potential warfarin control would simplify risk-benefit assessment of warfarin. Recently, HASBLED was demonstrated effective for this purpose, but this was in well-controlled patients with deep vein thrombosis. HASBLED as a predictor of warfarin control has not been validated in other populations including differing indications, warfarin control levels and ethnicities. The aim of this study was to determine whether HASBLED can predict warfarin control in patients with AF in Australia and Singapore. Retrospective data were collected for patients receiving warfarin between January and June 2014 in Australia and Singapore. Patient data were used to calculate HASBLED at the start and end of the study period. TTR was calculated for each patient, and mean TTR used for analysis to stratified HASBLED scores. Of the 4370 patients, there were 3199 in Australia and 1171 in Singapore with mean TTRs of 82% and 58%, respectively. At the start of the study, a HASBLED score ≥3 predicted significantly lower TTR in Singapore, whilst at the end of the study, this score identified patients with poor control in both Australia and Singapore. A HASBLED score ≥3 in patients treated with warfarin can differentiate significantly lower TTRs in Australian and Singapore patients with AF. HASBLED may assess bleed risk and warfarin control, identifying patients at high risk of poor warfarin outcome requiring additional INR monitoring or alternative anticoagulation.

• Authors: Nijole Bernaitis, Chi Keong Ching, Liping Chen, Jin Shing Hon, Siew Chong Teo, Tony Badrick, Andrew K Davey, Shailendra Anoopkumar-Dukie
• Journal: Basic & clinical pharmacology & toxicology (Basic Clin Pharmacol Toxicol) Vol. 121 Issue 6 Pg. 499-504 (Dec 2017) ISSN: 1742-7843 [Electronic] England
• PMID: 28639436 (Publication Type: Journal Article)
• Copyright: © 2017 Nordic Association for the Publication of BCPT (former Nordic Pharmacological Society).

Chemical References

• Anticoagulants
• Warfarin

Topics

• Aged
• Aged, 80 and over
• Algorithms
• Anticoagulants (therapeutic use)
• Asian People
• Atrial Fibrillation (complications, drug therapy)
• Australia
• Female
• Humans
• Hypertension (complications)
• International Normalized Ratio
• Male
• Middle Aged
• Retrospective Studies
• Risk Factors
• Singapore
• Stroke (etiology, prevention & control)
• Treatment Failure
• Warfarin (therapeutic use)
• White People