Drug development against tuberculosis: Impact of alkaloids.

Abstract

Despite of the advances made in the treatment and management, tuberculosis (TB) still remains one of main public health problem. The contrary effects of first and second-line anti-tuberculosis drugs have generated extended research interest in natural products in the hope of devising new antitubercular leads. Interestingly, plethoras of natural products have been discovered to exhibit activity towards various resistant strains of M. tuberculosis. Extensive applications of alkaloids in the field of therapeutics is well-established and nowday's researches being pursued to develop new potent drugs from natural sources for tuberculosis. Alkaloids are categorized in quite a few groups according to their structures and isolation from both terrestrial and marine sources. These new drugs might be a watershed in the battle against tuberculosis. This review summarizes alkaloids, which were found active against Mycobacteria since last ten years with special attention on the study of structure-activity relationship (SAR) and mode of action with their impact in drug discovery and development against tuberculosis.

• Authors: Shardendu K Mishra, Garima Tripathi, Navneet Kishore, Rakesh K Singh, Archana Singh, Vinod K Tiwari
• Journal: European journal of medicinal chemistry (Eur J Med Chem) Vol. 137 Pg. 504-544 (Sep 08 2017) ISSN: 1768-3254 [Electronic] France
• PMID: 28628823 (Publication Type: Journal Article, Review)
• Copyright: Copyright © 2017 Elsevier Masson SAS. All rights reserved.

Chemical References

• Alkaloids
• Antitubercular Agents

Topics

• Alkaloids (chemical synthesis, chemistry, pharmacology)
• Antitubercular Agents (chemical synthesis, chemistry, pharmacology)
• Dose-Response Relationship, Drug
• Drug Design
• Humans
• Microbial Sensitivity Tests
• Molecular Structure
• Mycobacterium tuberculosis (drug effects)
• Structure-Activity Relationship
• Tuberculosis (drug therapy)