Association of apolipoprotein A5 gene variants with metabolic syndrome in Tunisian population.

Abstract

AIM OF THE STUDY:

APOA5 has been linked to metabolic syndrome (MetS) or its traits in several populations. In North Africa, only the Moroccan population was investigated. Our aim is to assess the association between APOA5 gene polymorphisms with the susceptibility to MetS and its components in the Tunisian population.

MATERIALS AND METHODS:

A total of 594 participants from the Tunisian population were genotyped for two polymorphisms rs3135506 and rs651821 located in APOA5 gene using KASPar technology. Statistical analyses were performed using R software.

RESULTS:

The SNP rs651821 increased the risk of MetS under the dominant model (OR=1.91 [1.17-3.12], P=0.008) whereas the variant rs3135506 was not associated with MetS. After stratification of the cohort following the sex, only the variant rs651821 showed a significant association with MetS among the women group. The influence of the geographic origin of the studied population on the genotype distribution of APOA5 variants showed that the variant rs651821 was significantly associated with MetS only for the Northern population. The association analyses of the variants rs651821 and rs3135506 with different quantitative traits of MetS showed a significant association only between the variant rs3135506 and triglycerides levels.

CONCLUSION:

This is the first study reporting the association of APOA5 gene variants with MetS in Tunisia. Our study emphasizes the role of APOA5 variants in the regulation of the triglycerides blood levels. Further studies are needed to confirm the clinical relevance of these associations and to better understand the physiopathology of the MetS.

• Authors: Rym Kefi, Meriem Hechmi, Hamza Dallali, Sahar Elouej, Haifa Jmel, Yossra Ben Halima, Majdi Nagara, Mariem Chargui, Sihem Ben Fadhel, Safa Romdhane, Ines Kamoun, Zinet Turki, Abdelmajid Abid, Sonia Bahri, Afaf Bahlous, Ramon Gomis, Abdelhamid Baraket, Florin Grigorescu, Christophe Normand, Henda Jamoussi, Sonia Abdelhak
• Journal: Annales d'endocrinologie (Ann Endocrinol (Paris)) Vol. 78 Issue 3 Pg. 146-155 (Jul 2017) ISSN: 2213-3941 [Electronic] France
• PMID: 28624160 (Publication Type: Journal Article)
• Copyright: Copyright © 2017 Elsevier Masson SAS. All rights reserved.

Chemical References

• APOA5 protein, human
• Apolipoprotein A-V
• Triglycerides

Topics

• Adult
• Aged
• Apolipoprotein A-V (genetics)
• Case-Control Studies
• Female
• Gene Frequency
• Genetic Association Studies
• Genetic Predisposition to Disease
• Genotype
• Humans
• Lipid Metabolism (genetics)
• Male
• Metabolic Syndrome (blood, epidemiology, genetics)
• Middle Aged
• Phenotype
• Polymorphism, Single Nucleotide
• Triglycerides (blood)
• Tunisia (epidemiology)